Emmons Eric B, Ruggiero Rafael N, Kelley Ryan M, Parker Krystal L, Narayanan Nandakumar S
Department of Neurology, Carver College of Medicine, The University of Iowa Iowa City, IA, USA.
Department of Neurology, Carver College of Medicine, The University of IowaIowa City, IA, USA; Department of Neuroscience and Behavioral Sciences, University of São PauloSão Paulo, Brazil.
Front Psychol. 2016 Apr 5;7:459. doi: 10.3389/fpsyg.2016.00459. eCollection 2016.
Organizing movements in time is a critical and highly conserved feature of mammalian behavior. Temporal control of action requires corticostriatal networks. We investigate these networks in rodents using a two-interval timing task while recording LFPs in medial frontal cortex (MFC) or dorsomedial striatum. Consistent with prior work, we found cue-triggered delta (1-4 Hz) and theta activity (4-8 Hz) primarily in rodent MFC. We observed delta activity across temporal intervals in MFC and dorsomedial striatum. Rewarded responses were associated with increased delta activity in MFC. Activity in theta bands in MFC and delta bands in the striatum was linked with the timing of responses. These data suggest both delta and theta activity in frontostriatal networks are modulated during interval timing and that activity in these bands may be involved in the temporal control of action.
在时间上组织动作是哺乳动物行为的一个关键且高度保守的特征。动作的时间控制需要皮质纹状体网络。我们在啮齿动物中使用双间隔计时任务来研究这些网络，同时记录内侧前额叶皮质（MFC）或背内侧纹状体中的局部场电位（LFP）。与先前的研究一致，我们发现线索触发的δ波（1 - 4赫兹）和θ波活动（4 - 8赫兹）主要出现在啮齿动物的MFC中。我们在MFC和背内侧纹状体的整个时间间隔中观察到了δ波活动。奖励反应与MFC中δ波活动的增加有关。MFC中θ波段和纹状体中δ波段的活动与反应的时间有关。这些数据表明，前额叶纹状体网络中的δ波和θ波活动在间隔计时期间都会受到调制，并且这些波段的活动可能参与了动作的时间控制。
