托珠单抗联合环孢素治疗成人斯蒂尔病并发带状疱疹性脑膜炎
Herpes Zoster Meningitis Complicating Combined Tocilizumab and Cyclosporine Therapy for Adult-Onset Still's Disease.
作者信息
Tsurukawa Shinichiro, Iwanaga Nozomi, Izumi Yasumori, Shirakawa Atsunori, Kawahara Chieko, Shukuwa Tetsuo, Inamoto Miwako, Kawakami Atsushi, Migita Kiyoshi
机构信息
Department of Rheumatology, Clinical Research Center, NHO Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8562, Japan.
Department of Pharmacy, Clinical Research Center, NHO Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8562, Japan.
出版信息
Case Rep Rheumatol. 2016;2016:4232657. doi: 10.1155/2016/4232657. Epub 2016 Mar 22.
Abstract
A 56-year-old female with refractory adult-onset Still's disease presented with ocular herpes zoster infection during TCZ treatment. After three days of acyclovir treatment (5 mg/kg), she developed a severe headache and high fever. Viral DNA isolation and cerebral spinal fluid abnormalities led to a herpes zoster meningitis diagnosis. Her meningitis was cured by high doses of intravenous acyclovir (10 mg/kg for 14 days). To our knowledge, this is the first report of meningeal herpes zoster infection in rheumatic diseases under TCZ treatment.
摘要
一名56岁患有难治性成人斯蒂尔病的女性在托珠单抗（TCZ）治疗期间出现眼部带状疱疹感染。在接受阿昔洛韦治疗（5mg/kg）三天后，她出现了严重头痛和高热。病毒DNA分离及脑脊液异常导致带状疱疹脑膜炎的诊断。她的脑膜炎通过大剂量静脉注射阿昔洛韦（10mg/kg，持续14天）得以治愈。据我们所知，这是关于在TCZ治疗的风湿性疾病中发生脑膜带状疱疹感染的首例报告。
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