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Tumor-necrosis factor is a master of T cell exhaustion.

作者信息

Baxter Amy E, Kaufmann Daniel E

机构信息

Research Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Canada, and the Université de Montréal, Montreal, Canada.

出版信息

Nat Immunol. 2016 May;17(5):476-8. doi: 10.1038/ni.3436.

DOI:10.1038/ni.3436
PMID:27092797
Abstract
摘要

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Tumor-necrosis factor is a master of T cell exhaustion.肿瘤坏死因子是T细胞耗竭的主要因素。
Nat Immunol. 2016 May;17(5):476-8. doi: 10.1038/ni.3436.
2
Targeting PD-1 and Tim-3 Pathways to Reverse CD8 T-Cell Exhaustion and Enhance Ex Vivo T-Cell Responses to Autologous Dendritic/Tumor Vaccines.靶向程序性死亡受体1（PD-1）和T细胞免疫球蛋白黏蛋白3（Tim-3）通路以逆转CD8+ T细胞耗竭并增强体外T细胞对自体树突状细胞/肿瘤疫苗的反应
J Immunother. 2016 May;39(4):171-80. doi: 10.1097/CJI.0000000000000122.
3
CD8+ T Cells Specific to Apoptosis-Associated Antigens Predict the Response to Tumor Necrosis Factor Inhibitor Therapy in Rheumatoid Arthritis.凋亡相关抗原特异性CD8 + T细胞可预测类风湿关节炎患者对肿瘤坏死因子抑制剂治疗的反应。
PLoS One. 2015 Jun 10;10(6):e0128607. doi: 10.1371/journal.pone.0128607. eCollection 2015.
4
Blocking Tumor Necrosis Factor α Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma.阻断肿瘤坏死因子-α增强实验性黑色素瘤中 CD8 T 细胞依赖性免疫。
Cancer Res. 2015 Jul 1;75(13):2619-28. doi: 10.1158/0008-5472.CAN-14-2524. Epub 2015 May 14.
5
Treatment of established tumor is associated with ICAM-1 upregulation and reversed by CD8 depletion in a tumor necrosis factor-alpha gene transfected mouse mammary tumor.在肿瘤坏死因子-α基因转染的小鼠乳腺肿瘤中，对已形成肿瘤的治疗与细胞间黏附分子-1（ICAM-1）上调相关，且通过去除CD8细胞而逆转。
Pathobiology. 1999 Jul-Aug;67(4):186-95. doi: 10.1159/000028071.
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A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytes.转录因子NFATc2通过CD8 + T淋巴细胞在支气管腺癌中发挥关键调节作用。
Cancer Res. 2009 Apr 1;69(7):3069-76. doi: 10.1158/0008-5472.CAN-08-1678. Epub 2009 Mar 24.
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Perforin-independent CD8(+) T-cell-mediated cytotoxicity of alveolar epithelial cells is preferentially mediated by tumor necrosis factor-alpha: relative insensitivity to Fas ligand.穿孔素非依赖性CD8(+) T细胞介导的肺泡上皮细胞细胞毒性主要由肿瘤坏死因子-α介导：对Fas配体相对不敏感。
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Dendritic cells infected with vpr-positive human immunodeficiency virus type 1 induce CD8+ T-cell apoptosis via upregulation of tumor necrosis factor alpha.感染1型vpr阳性人类免疫缺陷病毒的树突状细胞通过上调肿瘤坏死因子α诱导CD8 + T细胞凋亡。
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Broadening CD4 and CD8 T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes.通过在交叉呈递脂质体中接种NS3重叠肽库来拓宽针对丙型肝炎病毒的CD4和CD8 T细胞应答。
J Virol. 2017 Jun 26;91(14). doi: 10.1128/JVI.00130-17. Print 2017 Jul 15.
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Hum Immunol. 2010 Dec;71(12):1187-90. doi: 10.1016/j.humimm.2010.08.006. Epub 2010 Aug 21.

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本文引用的文献

1
Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.肿瘤坏死因子损害慢性病毒感染中 CD4(+) T 细胞介导的免疫控制。
Nat Immunol. 2016 May;17(5):593-603. doi: 10.1038/ni.3399. Epub 2016 Mar 7.
2
Molecular and cellular insights into T cell exhaustion.对T细胞耗竭的分子和细胞层面的见解。
Nat Rev Immunol. 2015 Aug;15(8):486-99. doi: 10.1038/nri3862.
3
Persistent LCMV infection is controlled by blockade of type I interferon signaling.持续的 LCMV 感染受 I 型干扰素信号阻断的控制。
Identification of immunotherapy and radioimmunotherapy targets on desmoplastic small round cell tumors.
促纤维增生性小圆细胞肿瘤免疫治疗和放射免疫治疗靶点的鉴定
Front Oncol. 2023 Apr 5;13:1104693. doi: 10.3389/fonc.2023.1104693. eCollection 2023.
4
Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer.细胞自主型 CXCL1 通过中性粒细胞衍生的 TNF 在胰腺癌中维持耐受相关回路和基质炎症。
Cancer Discov. 2023 Jun 2;13(6):1428-1453. doi: 10.1158/2159-8290.CD-22-1046.
5
Chronic myeloid leukaemia patients at diagnosis and resistant to tyrosine kinase inhibitor therapy display exhausted T-cell phenotype.慢性髓性白血病患者在诊断时及对酪氨酸激酶抑制剂治疗耐药时表现出耗尽的 T 细胞表型。
Br J Haematol. 2022 Sep;198(6):1011-1015. doi: 10.1111/bjh.18302. Epub 2022 Jul 8.
6
Rapid and sustained decline in CXCL-10 (IP-10) annotates clinical outcomes following TNFα-antagonist therapy in hospitalized patients with severe and critical COVID-19 respiratory failure.CXCL-10（IP-10）的快速且持续下降预示着重度和危重型COVID-19呼吸衰竭住院患者接受肿瘤坏死因子α拮抗剂治疗后的临床结局。
J Clin Transl Sci. 2021 Jun 25;5(1):e146. doi: 10.1017/cts.2021.805. eCollection 2021.
7
[Role of tumor necrosis factor-α in infection in the urogenital tract of mice].[肿瘤坏死因子-α在小鼠泌尿生殖道感染中的作用]
Nan Fang Yi Ke Da Xue Xue Bao. 2020 Mar 30;40(3):388-393. doi: 10.12122/j.issn.1673-4254.2020.03.17.
8
In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory?健康人类妊娠的体内免疫特征：本质上是炎症性还是抗炎性？
PLoS One. 2017 Jun 21;12(6):e0177813. doi: 10.1371/journal.pone.0177813. eCollection 2017.
Science. 2013 Apr 12;340(6129):207-11. doi: 10.1126/science.1235214.
4
Blockade of chronic type I interferon signaling to control persistent LCMV infection.阻断慢性 I 型干扰素信号转导以控制持续性 LCMV 感染。
Science. 2013 Apr 12;340(6129):202-7. doi: 10.1126/science.1235208.
5
Nonpathogenic simian immunodeficiency virus infections.非致病性猴免疫缺陷病毒感染。
Cold Spring Harb Perspect Med. 2012 Jan;2(1):a007153. doi: 10.1101/cshperspect.a007153.
6
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.HIV特异性T细胞上的PD-1表达与T细胞耗竭及疾病进展相关。
Nature. 2006 Sep 21;443(7109):350-4. doi: 10.1038/nature05115. Epub 2006 Aug 20.
7
Tumor necrosis factor (TNF) system levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapy: persistent TNF activation is associated with virologic and immunologic treatment failure.高效抗逆转录病毒治疗期间人类免疫缺陷病毒感染患者的肿瘤坏死因子（TNF）系统水平：持续的TNF激活与病毒学和免疫学治疗失败相关。
J Infect Dis. 1999 Jan;179(1):74-82. doi: 10.1086/314572.
8
Serum levels of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptors in human immunodeficiency virus type 1 infection--correlations to clinical, immunologic, and virologic parameters.1型人类免疫缺陷病毒感染中肿瘤坏死因子-α（TNFα）和可溶性TNF受体的血清水平——与临床、免疫和病毒学参数的相关性
J Infect Dis. 1994 Feb;169(2):420-4. doi: 10.1093/infdis/169.2.420.
9
Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.肿瘤坏死因子α在慢性感染的T细胞克隆中诱导人类免疫缺陷病毒的表达。
Proc Natl Acad Sci U S A. 1989 Apr;86(7):2365-8. doi: 10.1073/pnas.86.7.2365.
10
Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.肿瘤坏死因子α和白细胞介素1通过激活核因子κB来刺激人类免疫缺陷病毒增强子。
Proc Natl Acad Sci U S A. 1989 Apr;86(7):2336-40. doi: 10.1073/pnas.86.7.2336.