血清素对大脑中脑源性神经营养因子（BDNF）及其前体proBDNF的调节作用。 - Suppr

Regulation of brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain by serotonin.

作者信息

Hashimoto Kenji

机构信息

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670, Japan.

出版信息

Eur Arch Psychiatry Clin Neurosci. 2016 Apr;266(3):195-7. doi: 10.1007/s00406-016-0682-9.

DOI:10.1007/s00406-016-0682-9

PMID:26899501

Abstract

摘要

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Regulation of brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain by serotonin.血清素对大脑中脑源性神经营养因子（BDNF）及其前体proBDNF的调节作用。

Eur Arch Psychiatry Clin Neurosci. 2016 Apr;266(3):195-7. doi: 10.1007/s00406-016-0682-9.

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Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience.脑源性神经营养因子（BDNF）前体肽、前BDNF和前原BDNF在大脑中的表达存在区域差异，这种差异赋予了应激恢复力。

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Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist.习得性无助大鼠模型脑区中脑源性神经营养因子（BDNF）及其前体proBDNF的变化以及TrkB激动剂和拮抗剂的抗抑郁作用。

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Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampus.早期丰富环境可诱导成年大鼠海马体中 proBDNF 向 BDNF 的转化率增加。

Behav Brain Res. 2014 May 15;265:76-83. doi: 10.1016/j.bbr.2014.02.022. Epub 2014 Feb 22.

Hippocampal proBDNF facilitates place learning strategy associated with neural activity in rats.海马体 proBDNF 促进了与大鼠神经活动相关的位置学习策略。

Brain Struct Funct. 2018 Dec;223(9):4099-4113. doi: 10.1007/s00429-018-1742-x. Epub 2018 Aug 27.

Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease.在阿尔茨海默病临床前期阶段，脑源性神经营养因子的前体形式和成熟脑源性神经营养因子均减少。

J Neurochem. 2005 Jun;93(6):1412-21. doi: 10.1111/j.1471-4159.2005.03135.x.

Whither proBDNF?前体脑源性神经营养因子何去何从？

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Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions.脑源性神经营养因子作为心境障碍的生物标志物：历史概述与未来方向。

Psychiatry Clin Neurosci. 2010 Aug;64(4):341-57. doi: 10.1111/j.1440-1819.2010.02113.x.

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Eur Arch Psychiatry Clin Neurosci. 2018 Mar;268(2):129-143. doi: 10.1007/s00406-016-0749-7. Epub 2016 Dec 2.

Eur Arch Psychiatry Clin Neurosci. 2016 Dec;266(8):765-769. doi: 10.1007/s00406-016-0693-6. Epub 2016 Apr 19.

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Eur Neuropsychopharmacol. 2015 Dec;25(12):2449-58. doi: 10.1016/j.euroneuro.2015.09.002. Epub 2015 Sep 9.

Ethnic differences in the serum levels of proBDNF, a precursor of brain-derived neurotrophic factor (BDNF), in mood disorders.情绪障碍中脑源性神经营养因子（BDNF）前体proBDNF血清水平的种族差异。

Eur Arch Psychiatry Clin Neurosci. 2016 Apr;266(3):285-7. doi: 10.1007/s00406-015-0641-x. Epub 2015 Sep 4.

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects.R-氯胺酮：一种起效迅速且作用持久的抗抑郁药，无拟精神病性副作用。

Transl Psychiatry. 2015 Sep 1;5(9):e632. doi: 10.1038/tp.2015.136.

Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin.缺乏脑血清素的小鼠中脑源性神经营养因子（BDNF）蛋白浓度升高。

Eur Arch Psychiatry Clin Neurosci. 2016 Apr;266(3):281-4. doi: 10.1007/s00406-015-0611-3. Epub 2015 Jun 23.

Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation.TrkB配体对炎症后小鼠抑郁样行为和树突变化的抗抑郁作用。

Int J Neuropsychopharmacol. 2014 Oct 31;18(4):pyu077. doi: 10.1093/ijnp/pyu077.

Regional differences in brain-derived neurotrophic factor levels and dendritic spine density confer resilience to inescapable stress.脑源性神经营养因子水平和树突棘密度的区域差异赋予了对不可逃避压力的适应能力。

Int J Neuropsychopharmacol. 2015 Jan 7;18(7):pyu121. doi: 10.1093/ijnp/pyu121.

The serotonin-BDNF duo: developmental implications for the vulnerability to psychopathology.血清素-脑源性神经营养因子对精神病理学易感性的发展影响。

Neurosci Biobehav Rev. 2014 Jun;43:35-47. doi: 10.1016/j.neubiorev.2014.03.012. Epub 2014 Apr 3.

Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484).血清脑源性神经营养因子浓度作为抑郁的外周表现：来自 179 项关联研究（N=9484）的系统评价和荟萃分析证据。

Mol Psychiatry. 2014 Jul;19(7):791-800. doi: 10.1038/mp.2013.105. Epub 2013 Aug 20.

Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression.Sigma-1 受体伴侣蛋白和脑源性神经营养因子：心血管疾病与抑郁症之间的新联系。

Prog Neurobiol. 2013 Jan;100:15-29. doi: 10.1016/j.pneurobio.2012.09.001. Epub 2012 Oct 5.

BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons.脑源性神经营养因子及其前肽储存在脑神经元的突触前致密核心囊泡中。

J Cell Biol. 2012 Mar 19;196(6):775-88. doi: 10.1083/jcb.201201038. Epub 2012 Mar 12.

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Regulation of brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain by serotonin.

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