补肾调冲方通过脑源性神经营养因子（BDNF）通路恢复卵巢储备功能减退。
Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway.
作者信息
Xia Tian, Fu Yu, Li Shuang, Ma Ruihong, Zhao Zhimei, Wang Baojuan, Chao Chune
机构信息
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Tianjin Chinese Traditional Medicine University, No. 314, Anshan West Road, Nankai District, Tianjin, 300193, People's Republic of China.
出版信息
J Assist Reprod Genet. 2016 Jun;33(6):795-805. doi: 10.1007/s10815-016-0697-1. Epub 2016 Apr 19.
PURPOSE
The purpose of this study was to explore the molecular pathway of BSTCR (Bu Shen Tiao Chong recipe) in retrieving diminished ovary reserve (DOR).
METHODS
The DOR model was established through injecting cyclophosphamide and the effect of BSTCR was examined under this background.
RESULTS
BSTCR was shown to restore depleted brain-derived neurotrophic factor (BDNF), CDC2, cyclin B, GSH1, and P38 levels as well as impaired oocyte maturation and the higher apoptosis induced in DOR. BSTCR also enhances the response of oocytes to in vitro fertilization, with higher implantation rate, birth rate, and placenta weight.
CONCLUSION
BSTCR might exert its beneficial role in oocyte maturation and restore DOR through regulating the BDNF pathway. And this pathway itself is probably through the consequence on several serum hormones such as FSH, E2, Inhibin B, etc.
目的
本研究旨在探索补肾调冲方（BSTCR）改善卵巢储备功能下降（DOR）的分子途径。
方法
通过注射环磷酰胺建立DOR模型，并在此背景下检测BSTCR的作用。
结果
结果显示，BSTCR可恢复DOR中脑源性神经营养因子（BDNF）、细胞周期蛋白依赖性激酶2（CDC2）、细胞周期蛋白B、谷胱甘肽1（GSH1）和P38水平，以及受损的卵母细胞成熟和较高的细胞凋亡。BSTCR还增强了卵母细胞对体外受精的反应，提高了着床率、出生率和胎盘重量。
结论
BSTCR可能通过调节BDNF途径在卵母细胞成熟中发挥有益作用并恢复DOR。而该途径本身可能是通过对几种血清激素如促卵泡生成素（FSH）、雌二醇（E2）、抑制素B等产生影响。
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