Gaillard Romy, Rifas-Shiman Sheryl L, Perng Wei, Oken Emily, Gillman Matthew W
The Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands.
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Obesity (Silver Spring). 2016 Jun;24(6):1320-7. doi: 10.1002/oby.21484. Epub 2016 Apr 20.
Maternal pre-pregnancy obesity is associated with offspring obesity. Underlying mechanisms may involve a maternal obesity-mediated proinflammatory state during pregnancy. Maternal C-reactive protein (CRP) level during pregnancy is a biomarker of low-grade systemic inflammation.
Among 1,116 mother-child pairs, this study examined associations of maternal second-trimester CRP plasma level, measured by high-sensitivity CRP arrays, with mid-childhood DXA fat mass index (FMI), trunk fat mass index (trunkFMI), fat-free mass index (FFMI), and early and mid-childhood BMI-z and waist circumference (WC). Main analyses were adjusted for maternal sociodemographic and lifestyle-related characteristics, gestational age at blood draw, and child's age and sex.
Higher maternal CRP level was associated with higher mid-childhood FMI and trunkFMI (adjusted difference: 0.15 kg/m(2) [95% CI: 0.01, 0.29] [P = 0.04] and 0.06 kg/m(2) [95% CI: 0.00, 0.12] [P = 0.06], per SD increment in maternal CRP, respectively), but not FFMI. Higher maternal CRP level was associated with higher early and mid-childhood BMI-z and WC in the basic models [P < 0.05], but these associations attenuated after adjustment for maternal characteristics (adjusted difference in early and mid-childhood BMI-z and WC: 0.05 [95% CI: -0.03, 0.13] [P = 0.20], 0.10 cm [95% CI: -0.17, 0.37] [P = 0.46], 0.07 [95% CI: -0.01, 0.14] [P = 0.09], 0.34 cm [95% CI: -0.25, 0.94] [P = 0.26], per SD increment in maternal CRP, respectively).
Higher second-trimester maternal CRP level was associated with higher mid-childhood overall and central adiposity.
孕前肥胖与子代肥胖相关。潜在机制可能涉及孕期母亲肥胖介导的促炎状态。孕期母亲C反应蛋白（CRP）水平是低度全身炎症的生物标志物。
在1116对母婴中，本研究通过高敏CRP检测阵列检测母亲孕中期血浆CRP水平，分析其与儿童中期双能X线吸收法脂肪量指数（FMI）、躯干脂肪量指数（trunkFMI）、去脂体重指数（FFMI）以及儿童早期和中期的BMI-Z评分和腰围（WC）之间的关联。主要分析对母亲的社会人口学和生活方式相关特征、采血时的孕周以及儿童的年龄和性别进行了校正。
母亲CRP水平较高与儿童中期较高的FMI和trunkFMI相关（校正差异分别为：每母亲CRP标准差增加0.15kg/m² [95%CI：0.01，0.29] [P = 0.04]和0.06kg/m² [95%CI：0.00，0.12] [P = 0.06]），但与FFMI无关。在基本模型中，母亲CRP水平较高与儿童早期和中期较高的BMI-Z评分及WC相关[P < 0.05]，但在对母亲特征进行校正后，这些关联减弱（儿童早期和中期BMI-Z评分及WC的校正差异分别为：每母亲CRP标准差增加0.05 [95%CI：-0.03，0.13] [P = 0.20]、0.10cm [95%CI：-0.17，0.37] [P = 0.46]、0.07 [95%CI：-0.01，0.14] [P = 0.09]、0.34cm [95%CI：-0.25，0.94] [P = 0.26]）。
孕中期母亲CRP水平较高与儿童中期较高的总体及中心性肥胖相关。
