Chopra K, Kundu S, Chowdhury D S
J Trop Pediatr. 1989 Feb;35(1):19-23. doi: 10.1093/tropej/35.1.19.
Sixty-two infants 1-12 months of age were administered five doses of trivalent oral polio vaccine (TOPV) at intervals of 4 weeks. The seroconversion achieved were 88.7, 93.5 and 96.5 per cent for type I, II, and III polioviruses. These seroconversion rates are significantly better when compared to seroconversion achieved after two and three doses of trivalent oral polio vaccine. Factors which were considered in previous studies to be responsible for low seroconversion rates viz. interference by enteroviruses, breast feeding, malnutrition, and age were found to be insignificant when five doses of oral polio vaccine were given. It is possible that these effects were overcome by increasing the number of doses of trivalent oral polio vaccine.
62名1至12个月大的婴儿每隔4周服用五剂三价口服脊髓灰质炎疫苗（TOPV）。I型、II型和III型脊髓灰质炎病毒的血清转化率分别为88.7%、93.5%和96.5%。与两剂和三剂三价口服脊髓灰质炎疫苗后的血清转化率相比，这些血清转化率明显更高。先前研究中认为导致血清转化率低的因素，即肠道病毒干扰、母乳喂养、营养不良和年龄，在服用五剂口服脊髓灰质炎疫苗时被发现并无显著影响。增加三价口服脊髓灰质炎疫苗的剂量可能克服了这些影响。
