不同促氧化剂和生理反应性的基于血红蛋白的氧载体（HBOC）的体内比较效应
Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.
作者信息
Toma Vlad Al, Farcaș Anca D, Roman Ioana, Sevastre Bogdan, Hathazi Denisa, Scurtu Florina, Damian Grigore, Silaghi-Dumitrescu Radu
机构信息
Biological Research Institute, Cluj Napoca, 400113, Romania.
Department of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, 400028, Romania.
出版信息
PLoS One. 2016 Apr 20;11(4):e0153909. doi: 10.1371/journal.pone.0153909. eCollection 2016.
A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on albumin as well as based on rubrerythrin appear to offer observable physiological advantages.
一系列基于血红蛋白的氧载体候选物（HBOC），此前因其促氧化和生理反应性的差异而受到关注，对它们在注射到Wistar大鼠体内时所表现出的负面影响进行了比较。在所测试的浓度下，基于白蛋白以及基于红氧还蛋白的抗氧化策略似乎具有明显的生理优势。
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