位于甲状腺峡部的乳头状甲状腺癌的临床病理特征及中央淋巴结转移模式
Clinicopathologic characteristics and pattern of central lymph node metastasis in papillary thyroid cancer located in the isthmus.
作者信息
Lee Young Chan, Na Se Young, Chung Hoon, Kim Su Il, Eun Young-Gyu
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
出版信息
Laryngoscope. 2016 Oct;126(10):2419-21. doi: 10.1002/lary.25926. Epub 2016 Apr 21.
OBJECTIVES/HYPOTHESIS: The aim of this study was to evaluate the clinicopathologic characteristics and pattern of lymph node (LN) metastasis in papillary thyroid cancer (PTC) located in the isthmus.
STUDY DESIGN
Retrospective cohort study.
METHODS
One hundred ninety consecutive patients with PTC who underwent total thyroidectomy and bilateral central neck dissection were analyzed. Preoperative ultrasonography was reviewed to identify PTC located in the isthmus. Clinicopathologic factors including age, sex, tumor size, extrathyroidal extension (ETE), margin, angiolymphatic invasion, and nodal metastasis were evaluated.
RESULTS
Of 190 PTC patients, 14 patients (7.3%) had a tumor located in the isthmus. The PTCs located in the isthmus were more likely to have ETE and central LN involvement. Furthermore, PTCs located in the isthmus had a higher frequency of metastasis to pretracheal and prelaryngeal LNs than those located in the lobes.
CONCLUSION
PTCs located in the isthmus were associated with ETE and more likely to involve the pretracheal and prelaryngeal LNs.
LEVEL OF EVIDENCE
4 Laryngoscope, 126:2419-2421, 2016.
目的/假设：本研究的目的是评估位于甲状腺峡部的乳头状甲状腺癌（PTC）的临床病理特征及淋巴结（LN）转移模式。
研究设计
回顾性队列研究。
方法
分析190例连续接受全甲状腺切除术及双侧中央区颈淋巴结清扫术的PTC患者。回顾术前超声检查以确定位于甲状腺峡部的PTC。评估包括年龄、性别、肿瘤大小、甲状腺外侵犯（ETE）、切缘、脉管侵犯及淋巴结转移等临床病理因素。
结果
190例PTC患者中，14例（7.3%）肿瘤位于甲状腺峡部。位于甲状腺峡部的PTC更易发生甲状腺外侵犯及中央区淋巴结受累。此外，位于甲状腺峡部的PTC转移至气管前和喉前淋巴结的频率高于位于甲状腺叶的PTC。
结论
位于甲状腺峡部的PTC与甲状腺外侵犯相关，且更易累及气管前和喉前淋巴结。
证据级别
4 喉镜，126:2419 - 2421，2016年。
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