Li Jing, Yang Yi-Quan, Yang Di-Ya, Liu Xiang-Xiang, Sun Yun-Xiao, Wei Shi-Fei, Wang Ning-Li
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.
Chin Med J (Engl). 2016 May 5;129(9):1087-90. doi: 10.4103/0366-6999.180532.
Optical coherence tomography (OCT) angiography is a novel technique by which we can detect the local perfusion of fundus directly. The aim of this study was to evaluate the reproducibility of optic disc and macular flow perfusion parameters in rhesus monkeys using OCT angiography.
Eighteen healthy monkeys (18 eyes) were subjected to optic disc and macula flow index measurements via a high-speed and high-resolution spectral-domain OCT XR Avanti with a split-spectrum amplitude de-correlation angiography algorithm. Right eye was imaged 3 times during the first examination and once during each of the two following examinations. The intra-visit and inter-visit intraclass correlation coefficients (ICCs) were both determined.
The average flow indices of the four optic disc area layers were 0.171 ± 0.009 (optic nerve head), 0.015 ± 0.004 (vitreous), 0.052 ± 0.009 (radial peripapillary capillary), and 0.167 ± 0.011 (choroid). Average flow indices of the four macula area layers were 0.044 ± 0.011 (superficial retina), 0.036 ± 0.011 (deep retina), 0.016 ± 0.009 (outer retina), and 0.155 ± 0.013 (choroid). Intra-visit (ICC value: 0.821-0.954) and inter-visit (ICC value: 0.844-0.899) repeatability were both high.
The study is about the reproducibility of optic disc and macular perfusion parameters as measured by OCT angiography in healthy rhesus monkeys. Flow index measurement reproducibility is high for both the optic disc and macula of normal monkey eyes. OCT angiography might be a useful technique to assess changes when examining monkeys with experimental ocular diseases.
光学相干断层扫描血管造影术（OCTA）是一种能够直接检测眼底局部血流灌注的新技术。本研究旨在评估使用OCTA测量恒河猴视盘和黄斑血流灌注参数的可重复性。
对18只健康猴子（18只眼）使用具有分裂谱幅度去相关血管造影算法的高速高分辨率光谱域OCT XR Avanti对视盘和黄斑血流指数进行测量。右眼在首次检查时成像3次，在随后的两次检查中每次成像1次。分别测定了检查内和检查间的组内相关系数（ICC）。
视盘四个区域层的平均血流指数分别为0.171±0.009（视神经乳头）、0.015±0.004（玻璃体）、0.052±0.009（视乳头周围放射状毛细血管）和0.167±0.011（脉络膜）。黄斑四个区域层的平均血流指数分别为0.044±0.011（视网膜浅层）、0.036±0.011（视网膜深层）、0.016±0.009（视网膜外层）和0.155±0.013（脉络膜）。检查内（ICC值：0.821 - 0.954）和检查间（ICC值：0.844 - 0.899）的重复性均较高。
本研究探讨了OCTA测量健康恒河猴视盘和黄斑灌注参数的可重复性。正常猴眼视盘和黄斑的血流指数测量可重复性均较高。OCTA可能是一种在检查患有实验性眼病的猴子时评估变化的有用技术。
