Alnawaiseh Maged, Brand Cristin, Bormann Eike, Sauerland Cristina, Eter Nicole
Department of Ophthalmology, University of Muenster Medical Center, Albert-Schweitzer-Campus 1, Building D15, 48149, Muenster, Germany.
Centre of Reproductive Medicine and Andrology, University of Muenster, Muenster, Germany.
BMC Ophthalmol. 2018 May 24;18(1):123. doi: 10.1186/s12886-018-0789-z.
The aim of the study was to evaluate the impact of integration of the eye-tracking system (ET) on the repeatability of flow density measurements using optical coherence tomography (OCT) angiography.
20 healthy subjects were included in this study. OCT-angiography was performed using RTVue XR Avanti (Optovue Inc., Fremont, California, USA). The macula was imaged using a 3 × 3 mm scan twice with and twice without activation of the ET. Flow density data of the macular in the superficial and deep OCT angiograms were extracted and analyzed.
The difference between the flow density (whole en face) in the first session and second session with and without ET was statistically non-significant (with ET: superficial retinal OCT angiogram: p = 0.50; deep retinal OCT angiogram: p = 0.89; without ET: superficial retinal OCT angiogram: p = 0.81; deep retinal OCT angiogram: p = 0.24). There was no significant difference in the coefficients of repeatability for measurements with and without ET in the superficial retinal OCT angiogram (adjusted p-value = 0.176), whereas the difference was significant for the deep retinal OCT angiogram (adjusted p-value = 0.008).
Integration of the ET improved the repeatability of flow density measurements in the deep OCT angiogram; this needs to be considered when evaluating the long-term changes of flow density and when comparing data of different studies and different devices.
本研究的目的是评估眼动追踪系统（ET）的整合对使用光学相干断层扫描（OCT）血管造影术进行血流密度测量的可重复性的影响。
本研究纳入了20名健康受试者。使用RTVue XR Avanti（美国加利福尼亚州弗里蒙特市Optovue公司）进行OCT血管造影。在激活ET和未激活ET的情况下，对黄斑进行3×3mm扫描，各成像两次。提取并分析表层和深层OCT血管造影图中黄斑的血流密度数据。
在有ET和无ET的情况下，第一次和第二次测量的血流密度（整个正面图像）之间的差异无统计学意义（有ET：表层视网膜OCT血管造影图：p = 0.50；深层视网膜OCT血管造影图：p = 0.89；无ET：表层视网膜OCT血管造影图：p = 0.81；深层视网膜OCT血管造影图：p = 0.24）。在表层视网膜OCT血管造影图中，有ET和无ET测量的重复性系数无显著差异（校正p值 = 0.176），而在深层视网膜OCT血管造影图中差异显著（校正p值 = 0.008）。
ET的整合提高了深层OCT血管造影图中血流密度测量的可重复性；在评估血流密度的长期变化以及比较不同研究和不同设备的数据时需要考虑这一点。
