Montull S, Parés A, Bruguera M, Caballería J, Uchida T, Rodés J
Liver Unit, Universitat de Barcelona, Spain.
Liver. 1989 Apr;9(2):79-85. doi: 10.1111/j.1600-0676.1989.tb00383.x.
Among 389 consecutive chronic alcoholics in whom a liver biopsy was performed for diagnostic purposes, nine patients (2.3%) had histological changes of "alcoholic foamy degeneration" (AFD), characterized by numerous small fat droplets in the swollen hepatocytes of the centrilobular area. In five cases, there were non-specific clinical features, while the other four cases presented acute hepatic decompensation with jaundice and a reduced prothrombin activity. Seven patients had high serum lipid concentrations including hypertriglyceridemia and hypercholesterolemia, which improved after withdrawal of alcohol intake. In conclusion, AFD has a broad clinicopathological spectrum including asymptomatic patients and other cases with severe liver decompensation manifested by jaundice and reduced prothrombin activity. AFD is usually associated with hyperlipemia.
在389例因诊断目的而接受肝脏活检的连续慢性酒精中毒患者中，9例（2.3%）出现了“酒精性泡沫样变性”（AFD）的组织学改变，其特征是小叶中心区肿胀的肝细胞内有大量小脂肪滴。5例有非特异性临床特征，另外4例表现为伴有黄疸和凝血酶原活性降低的急性肝失代偿。7例患者血脂浓度升高，包括高甘油三酯血症和高胆固醇血症，戒酒治疗后血脂浓度改善。总之，AFD具有广泛的临床病理谱，包括无症状患者以及其他表现为黄疸和凝血酶原活性降低的严重肝失代偿病例。AFD通常与高脂血症相关。
