Veisani Yousef, Delpisheh Ali
Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Department of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran.
Gastroenterol Hepatol Bed Bench. 2016 Spring;9(2):78-86.
In this study, we aimed to estimate one- to five-year survival rates in Iranian patients with gastric cancer (GC). In addition, we preformed subgroup analyses and meta-regression to explore possible sources of heterogeneity between studies.
According to literatures, there has been increasing attention to the long-term survival rate in patients with GC in Iran. However, results have been inconsistent and remain controversial in overall survival rates.
Literature searches were conducted using PubMed, Scopus, and ISI, as well as Magiran, Medlib, SID, and Iran Medex databases. Studies were pooled and summary one to five survival rates were calculated. Univariate and multivariate regression analyses were used to explore possible sources of heterogeneity among studies. Subgroup analyses were also conducted. Analyses were conducted using the STATA statistical software package.
Final analysis of 29361 patients from 26 eligible studies was performed. The overall survival rate (one to five years) in all studies, by meta-analysis of 24, 14, 23, 12 and 22 studies were 52%, 31%, 24%, 22%, and 15%, respectively. Meta-regression analysis showed an increase in one- and five-year survival rate over the time (Reg Coef = 0.016, p= 0.04) and (Reg Coef= 0.021, p= 0.049), respectively. Positive heterogeneity was observed between quality of papers and data sources (P<0.001).
More than half of GC deaths happened in the first year at diagnosis, and another 30% plus they occurred during the second year after confirmed diagnosis. Our results admit lower survival rates in Iran, similar to other developing countries.
在本研究中，我们旨在估算伊朗胃癌（GC）患者的1至5年生存率。此外，我们进行了亚组分析和meta回归，以探究研究间异质性的可能来源。
根据文献，伊朗对GC患者的长期生存率越来越关注。然而，总体生存率的结果一直不一致且仍存在争议。
使用PubMed、Scopus和ISI以及Magiran、Medlib、SID和Iran Medex数据库进行文献检索。汇总研究并计算1至5年生存率的汇总数据。使用单变量和多变量回归分析来探究研究间异质性的可能来源。还进行了亚组分析。使用STATA统计软件包进行分析。
对来自26项合格研究的29361例患者进行了最终分析。通过对24、14、23、12和22项研究的meta分析，所有研究的总体生存率（1至5年）分别为52%、31%、24%、22%和15%。Meta回归分析显示，1年和5年生存率随时间增加（回归系数分别为0.016，p = 0.04）和（回归系数 = 0.021，p = 0.049）。在论文质量和数据来源之间观察到正异质性（P<0.001）。
超过一半的GC死亡发生在诊断后的第一年，确诊后的第二年又有30%以上的死亡发生。我们的结果表明伊朗的生存率较低，与其他发展中国家类似。
