Zhu Tong, Marschall Henrik, Hansen Karina E, Horne Andrew W, Saraswat Lucky, Zondervan Krina T, Missmer Stacey A, Hummelshoj Lone, Bokor Atilla, Østrup Camilla S, Melgaard Anna, Rytter Dorte
Department of Public Health, Aarhus University, Aarhus, Denmark.
Centre for Reproductive Health, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
BJOG. 2025 Apr;132(5):656-662. doi: 10.1111/1471-0528.18066. Epub 2025 Jan 13.
To build consensus on most important symptoms and related consequences for use in questionnaires to characterise individuals with suspected and confirmed endometriosis in the general population.
A questionnaire of 107 symptoms and related consequences of endometriosis was collaboratively developed by patients, medical doctors and researchers and further assessed in a two-round e-Delphi study. Participants assessed the relevance of the symptoms, and a priori it was decided that 70% was the threshold for inclusion of a symptom.
Participants represented 7 countries, including Australia, Denmark, France, Hungary, the United Kingdom, the United States, and Turkey.
Individuals with endometriosis, medical doctors and researchers with expertise in endometriosis.
A modified e-Delphi study.
Consensus-based selection of symptoms for endometriosis questionnaires.
Seventy-six participants completed the first Delphi round and 65 completed the second round. Four symptoms met consensus in the first round (menstrual pain, pain during sexual intercourse, cyclic pain during defecation, and infertility), with two additional symptoms reaching consensus in the second round (cyclic pain and increased doctor/health care contacts for abdominal/pelvic pain).
This study highlighted six symptoms relevant for inclusion in endometriosis research questionnaires: menstrual pain, pain during sexual intercourse, cyclic pain during defecation, cyclic pain, infertility, and a high number of doctor/health care visits due to abdominal/pelvic pain. Recognising a broad range of potential symptoms is essential for raising awareness and supporting early detection efforts.
就用于问卷调查的最重要症状及相关后果达成共识，以对普通人群中疑似和确诊的子宫内膜异位症患者进行特征描述。
由患者、医生和研究人员共同编制了一份包含107种子宫内膜异位症症状及相关后果的问卷，并在两轮电子德尔菲研究中进一步评估。参与者评估了这些症状的相关性，并且事先确定70%为纳入一种症状的阈值。
参与者代表7个国家，包括澳大利亚、丹麦、法国、匈牙利、英国、美国和土耳其。
子宫内膜异位症患者、在子宫内膜异位症方面具有专业知识的医生和研究人员。
一项改良的电子德尔菲研究。
基于共识选择子宫内膜异位症问卷的症状。
76名参与者完成了第一轮德尔菲调查，65名完成了第二轮。有4种症状在第一轮达成共识（痛经、性交痛、周期性排便疼痛和不孕），另有2种症状在第二轮达成共识（周期性疼痛以及因腹部/盆腔疼痛而增加看医生/就医次数）。
本研究突出了6种与纳入子宫内膜异位症研究问卷相关的症状：痛经、性交痛、周期性排便疼痛、周期性疼痛、不孕以及因腹部/盆腔疼痛而频繁看医生/就医。认识到广泛的潜在症状对于提高认识和支持早期检测工作至关重要。
