Grotz C, Meillon C, Amieva H, Stern Y, Dartigues J-F, Adam S, Letenneur L
Catherine Grotz, Unité de Psychologie de la Sénescence, University of Liège, Traverse des Architectes (B63c) - Sart Tilman, B-4000 Liège, Belgium, Phone number: + 32 4 366 28 46; e-mail:
J Nutr Health Aging. 2016;20(5):514-9. doi: 10.1007/s12603-015-0599-4.
To determine whether and how age at retirement influences the risk of dementia. The association between the age at retirement, the number of working years and the risk of dementia was evaluated over 12 years of follow-up.
A prospective population-based study.
Three-City cohort, a French population-based study of community-dwelling individuals aged 65 to 95.
The sample consisted of 1,658 non-demented participants at baseline.
All participants were evaluated at home at the initial visit and at two years interval for a period of 12 years. An active research of dementia was conducted at each follow-up; all suspected cases were analysed by an independent committee of neurologists. Information regarding retirement age and number of working years was collected at baseline using a structured questionnaire.
The multivariate Cox model, including both the age at retirement and the number of working years and adjusted for potential confounders, revealed that the risk of dementia was independently associated with the age at retirement (p=0.022) but not with the number of working years (p=0.296).
Although our results are in accordance with previous studies (i.e., older age at retirement is associated with decreased risk of dementia), it provides additional information regarding the possible explanation for such results. Given that a longer working life did not reduce the risk of dementia, the age at retirement cannot be considered as a new factor of cognitive reserve but rather seems to be a psycho-social vulnerability factor. Further evidence is necessary to identify work and retirement related factors that influence the association between the age at retirement and the risk of dementia.
确定退休年龄是否以及如何影响患痴呆症的风险。在12年的随访中评估了退休年龄、工作年限与痴呆症风险之间的关联。
一项基于人群的前瞻性研究。
三城市队列研究，一项针对65至95岁社区居住个体的法国人群研究。
样本包括1658名基线时无痴呆症的参与者。
所有参与者在初次访视时在家中接受评估，并在12年期间每隔两年评估一次。每次随访时都积极开展痴呆症研究；所有疑似病例均由一个独立的神经科医生委员会进行分析。在基线时使用结构化问卷收集有关退休年龄和工作年限的信息。
多变量Cox模型，包括退休年龄和工作年限，并对潜在混杂因素进行了调整，结果显示痴呆症风险与退休年龄独立相关（p = 0.022），但与工作年限无关（p = 0.296）。
尽管我们的结果与先前的研究一致（即退休年龄较大与痴呆症风险降低相关），但它提供了有关此类结果可能解释的更多信息。鉴于较长的工作寿命并未降低痴呆症风险，退休年龄不能被视为认知储备的新因素，而似乎是一个心理社会脆弱性因素。需要进一步的证据来确定影响退休年龄与痴呆症风险之间关联的工作和退休相关因素。
