甲氨蝶呤所致急性淋巴细胞白血病患儿吸收不良
Methotrexate-induced malabsorption in children with acute lymphoblastic leukaemia.
作者信息
Craft A W, Kay H, Lawson D N, McElwain T J
出版信息
Br Med J. 1977 Dec 10;2(6101):1511-2. doi: 10.1136/bmj.2.6101.1511.
Abstract
A one-hour D-xylose absorption test was performed on 18 children with acute lymphoblastic leukaemia. Xylose absorption was normal in children who had not received methotrexate, but there was a significant degree of malabsorption in those who had taken methotrexate within the previous seven days. There was a progressive and significant increase in malabsorption related to the cumulative dose of methotrexate. These findings provide further evidence that regular methotrexate treatment every seven days is more toxic than if it is more widely spaced. The spacing of treatment is currently under investigation.
摘要
对18名急性淋巴细胞白血病患儿进行了1小时的D-木糖吸收试验。未接受甲氨蝶呤治疗的患儿木糖吸收正常，但在过去7天内接受过甲氨蝶呤治疗的患儿存在明显程度的吸收不良。吸收不良与甲氨蝶呤的累积剂量呈渐进性显著增加。这些发现进一步证明，每7天进行一次常规甲氨蝶呤治疗比延长给药间隔的毒性更大。目前正在对治疗间隔进行研究。
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