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胎儿皮质移植可减轻新生大鼠额叶皮质损伤所致的丘脑萎缩。

Fetal cortical transplants reduce the thalamic atrophy induced by frontal cortical lesions in newborn rats.

作者信息

Sørensen J C, Zimmer J, Castro A J

机构信息

Department of Anatomy, Loyola University, Stritch School of Medicine, Maywood, IL 60153.

出版信息

Neurosci Lett. 1989 Mar 13;98(1):33-8. doi: 10.1016/0304-3940(89)90369-8.

DOI:10.1016/0304-3940(89)90369-8
PMID:2710397
Abstract

Fetal neocortical tissue was grafted into frontal cortex lesion cavities made in newborn rats. After survival periods extending up to 14 months, volumetric measurements of the total thalamus and of the lateral, medial and anterior thalamic compartments showed an amelioration of the thalamic atrophy that normally is found after cortical lesions. These results correspond to previous findings demonstrating interconnections between fetal cortical transplants and the host thalamus.

摘要

将胎儿新皮质组织移植到新生大鼠额叶皮质损伤腔中。在长达14个月的存活期后,对整个丘脑以及丘脑外侧、内侧和前侧部分进行体积测量,结果显示丘脑萎缩有所改善,而丘脑萎缩通常在皮质损伤后出现。这些结果与之前的研究结果一致,这些研究表明胎儿皮质移植与宿主丘脑之间存在相互联系。

相似文献

1
Fetal cortical transplants reduce the thalamic atrophy induced by frontal cortical lesions in newborn rats.胎儿皮质移植可减轻新生大鼠额叶皮质损伤所致的丘脑萎缩。
Neurosci Lett. 1989 Mar 13;98(1):33-8. doi: 10.1016/0304-3940(89)90369-8.
2
Transplants of fetal frontal cortex grafted into the occipital cortex of newborn rats receive a substantial thalamic input from nuclei normally projecting to the frontal cortex.移植到新生大鼠枕叶皮质的胎儿额叶皮质会从通常投射到额叶皮质的核团接收大量丘脑输入。
Neuroscience. 1999 Mar;89(2):409-21. doi: 10.1016/s0306-4522(98)00379-0.
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Fetal cortical transplants ameliorate thalamic atrophy ipsilateral to neonatal frontal cortex lesions.胎儿皮质移植可改善新生儿额叶皮质损伤同侧的丘脑萎缩。
Neurosci Lett. 1986 Nov 11;71(2):247-51. doi: 10.1016/0304-3940(86)90567-7.
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Fetal frontal cortex transplanted to injured motor/sensory cortex of adult rats: reciprocal connections with host thalamus demonstrated with WGA-HRP.
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Heterotopic neocortical transplants. An anatomical and electrophysiological analysis of host projections to occipital cortical grafts placed into sensorimotor cortical lesions made in newborn rats.异位新皮层移植。对植入新生大鼠感觉运动皮层损伤部位的枕叶皮层移植物的宿主投射进行解剖学和电生理学分析。
Brain Res Dev Brain Res. 1991 Feb 22;58(2):231-6. doi: 10.1016/0165-3806(91)90009-8.
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Attraction exerted in vivo by grafts of embryonic neocortex on developing thalamic axons.胚胎新皮层移植在体内对发育中的丘脑轴突产生的吸引力。
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Specific invasion of occipital-to-frontal neocortical grafts by axons from the lateral posterior thalamic nucleus consecutive to neonatal lesion of the rat occipital cortex.大鼠枕叶皮质新生期损伤后,外侧后丘脑核轴突对枕叶至额叶新皮质移植组织的特异性侵入。
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Efferents of frontal or occipital cortex grafted into adult rat's motor cortex.移植到成年大鼠运动皮层的额叶或枕叶皮层的传出神经。
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Development of projections from transplants of embryonic medial or lateral frontal cortex placed in the lateral frontal cortex of newborn hosts.
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Transplantation of fetal frontal cortex onto degenerating thalamus of cats and kittens.将胎儿额叶皮质移植到猫和小猫退化的丘脑上。
Dev Neurosci. 1990;12(1):1-10. doi: 10.1159/000111830.

引用本文的文献

1
Embryonic amygdalar transplants in adult rats with motor cortex lesions: a molecular and electrophysiological analysis.胚胎杏仁核移植入成年大鼠运动皮层损伤后:分子和电生理分析。
Front Neurol. 2011 Sep 15;2:59. doi: 10.3389/fneur.2011.00059. eCollection 2011.
2
Microglial reactions to retrograde degeneration of tracer-identified thalamic neurons after frontal sensorimotor cortex lesions in adult rats.成年大鼠额叶感觉运动皮层损伤后,小胶质细胞对示踪剂标记的丘脑神经元逆行性变性的反应。
Exp Brain Res. 1996 Nov;112(2):203-12. doi: 10.1007/BF00227639.
3
Connectivity of fetal neocortical block transplants in the excitotoxically ablated cortex of adult rats.
成年大鼠兴奋性毒素损伤皮质中胎儿新皮质块移植的连接性
Exp Brain Res. 1993;96(3):480-6. doi: 10.1007/BF00234115.
4
Projections from fetal neocortical transplants placed in the frontal neocortex of newborn rats. A Phaseolus vulgaris-leucoagglutinin tracing study.置于新生大鼠额叶新皮质的胎儿新皮质移植的投射。一项菜豆白细胞凝集素追踪研究。
Exp Brain Res. 1992;92(2):299-309. doi: 10.1007/BF00227972.