Rahimlou Mehran, Yari Zahra, Hekmatdoost Azita, Alavian Seyed Moayed, Keshavarz Seyed Ali
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, IR Iran; Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallh University of Medical Sciences, Tehran, IR Iran.
Department of Nutrition, Faculty of Nutrition and Dietetics, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Hepat Mon. 2016 Jan 23;16(1):e34897. doi: 10.5812/hepatmon.34897. eCollection 2016 Jan.
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. The pathogenesis of this disease is closely associated with obesity and insulin resistance. Ginger can have hypolipidemic and antioxidant effects, and act as an insulinsensitizer.
The aim of this study was to evaluate the effects of ginger supplementation in NAFLD management.
In a randomized, double-blind, placebo-controlled clinical trial, 44 patients with NAFLD were assigned to take either two grams per day of a ginger supplement or the identical placebo, for 12 weeks. In both groups, patients were advised to follow a modified diet and physical activity program. The metabolic parameters and indicators of liver damage were measured at study baseline and after the 12 week intervention.
Ginger supplementation resulted in a significant reduction in alanine aminotransferase, γ-glutamyl transferase, inflammatory cytokines, as well as the insulin resistance index and hepatic steatosis grade in comparison to the placebo. We did not find any significant effect of taking ginger supplements on hepatic fibrosis and aspartate aminotransferase.
Twelve weeks of two grams of ginger supplementation showed beneficial effects on some NAFLD characteristics. Further studies are recommended to assess the long-term supplementation effects.
非酒精性脂肪性肝病（NAFLD）是全球最常见的慢性肝病之一。该疾病的发病机制与肥胖和胰岛素抵抗密切相关。生姜具有降血脂和抗氧化作用，并可作为胰岛素增敏剂。
本研究旨在评估补充生姜对非酒精性脂肪性肝病管理的影响。
在一项随机、双盲、安慰剂对照临床试验中，44例非酒精性脂肪性肝病患者被分配为每天服用2克生姜补充剂或相同的安慰剂，为期12周。两组患者均被建议遵循改良饮食和体育活动计划。在研究基线和12周干预后测量代谢参数和肝损伤指标。
与安慰剂相比，补充生姜导致丙氨酸转氨酶、γ-谷氨酰转移酶、炎性细胞因子以及胰岛素抵抗指数和肝脂肪变性分级显著降低。我们未发现服用生姜补充剂对肝纤维化和天冬氨酸转氨酶有任何显著影响。
连续12周每天补充2克生姜对非酒精性脂肪性肝病的某些特征显示出有益效果。建议进一步研究以评估长期补充的效果。
