Rafie Roya, Hosseini Seyed Ahmad, Hajiani Eskandar, Saki Malehi Amal, Mard Seyed Ali
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Research Center for Infectious Diseases of the Digestive System, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Clin Exp Gastroenterol. 2020 Jan 23;13:35-45. doi: 10.2147/CEG.S234698. eCollection 2020.
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders. The main causes of NAFLD are associated with insulin resistance, severe lipid metabolism disorders, oxidative stress and inflammation. Previous studies have reported that ginger has positive metabolic results.
The aim of this study was to determine the effect of ginger powder supplement on lipid profiles, insulin resistance, liver enzymes, inflammatory cytokines and antioxidant status in patients with NAFLD.
In this randomized clinical trial, 46 people with NAFLD were parted into two groups and subjected to the ginger or placebo capsules (3 capsules daily, each containing 500 mg of ginger or wheat flour) over 12 weeks. All patients received a diet with balanced energy and physical activity during the intervention period. Liver ultrasonography, anthropometric indices and biochemical parameters were measured before and after intervention.
No significant difference was found between the two groups in the baseline variables at the beginning of the study. At the end of the study, serum levels of alanine aminotransferase (ALT), total cholesterol, low-density lipoprotein (LDL-C), fasting blood glucose, and insulin resistance index (HOMA), C-reactive protein (hs-CRP), and fetuin-A in the group receiving a ginger supplement significantly decreased compared to placebo. However, there was no significant difference between the two groups in body weight, fasting insulin, HDL-C, triglyceride, adiponectin, alpha-tumor necrosis factor (TNF-α), total antioxidant capacity (TAC), gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), fatty liver index (FLI), fatty liver grade and blood pressure.
The ginger supplement may be used as a complementary therapy along with existing therapies to reduce insulin resistance, liver enzymes and inflammation in patients with non-alcoholic fatty liver.
非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝脏疾病之一。NAFLD的主要病因与胰岛素抵抗、严重的脂质代谢紊乱、氧化应激和炎症有关。先前的研究报道生姜具有积极的代谢作用。
本研究旨在确定补充姜粉对NAFLD患者血脂谱、胰岛素抵抗、肝酶、炎性细胞因子和抗氧化状态的影响。
在这项随机临床试验中，46例NAFLD患者被分为两组，在12周内分别服用生姜或安慰剂胶囊（每日3粒，每粒含500毫克生姜或小麦粉）。在干预期内，所有患者均接受能量均衡的饮食和体育锻炼。在干预前后测量肝脏超声、人体测量指标和生化参数。
研究开始时，两组的基线变量无显著差异。研究结束时，与安慰剂组相比，服用生姜补充剂组的血清丙氨酸转氨酶（ALT）、总胆固醇、低密度脂蛋白（LDL-C）、空腹血糖和胰岛素抵抗指数（HOMA）、C反应蛋白（hs-CRP）和胎球蛋白-A显著降低。然而，两组在体重、空腹胰岛素、高密度脂蛋白胆固醇（HDL-C）、甘油三酯、脂联素、α肿瘤坏死因子（TNF-α）、总抗氧化能力（TAC）、γ-谷氨酰转移酶（GGT）、天冬氨酸转氨酶（AST）、脂肪肝指数（FLI）、脂肪肝分级和血压方面无显著差异。
生姜补充剂可与现有疗法一起作为辅助疗法，以降低非酒精性脂肪肝患者的胰岛素抵抗、肝酶和炎症。
