Mohammadian Kiana, Fakhar Fatemeh, Keramat Shayan, Stanek Agata
Division of Hematology and Blood Banking, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz 71348, Iran.
VAS-European Independent Foundation in Angiology/Vascular Medicine, Via GB Grassi 74, 20157 Milan, Italy.
Antioxidants (Basel). 2024 Jun 29;13(7):797. doi: 10.3390/antiox13070797.
Non-alcoholic fatty liver disease (NAFLD) is a global public health problem that causes liver-related morbidity and mortality. It is also an independent risk factor for non-communicable diseases. In 2020, a proposal was made to refer to it as "metabolic dysfunction-associated fatty liver disease (MAFLD)", with concise diagnostic criteria. Given its widespread occurrence, its treatment is crucial. Increased levels of oxidative stress cause this disease. This review aims to evaluate various studies on antioxidant therapies for patients with MAFLD. A comprehensive search for relevant research was conducted on the PubMed, SCOPUS, and ScienceDirect databases, resulting in the identification of 87 studies that met the inclusion criteria. In total, 31.1% of human studies used natural antioxidants, 53.3% used synthetic antioxidants, and 15.5% used both natural and synthetic antioxidants. In human-based studies, natural antioxidants showed 100% efficacy in the treatment of MAFLD, while synthetic antioxidants showed effective results in only 91% of the investigations. In animal-based research, natural antioxidants were fully effective in the treatment of MAFLD, while synthetic antioxidants demonstrated effectiveness in only 87.8% of the evaluations. In conclusion, antioxidants in their natural form are more helpful for patients with MAFLD, and preserving the correct balance of pro-oxidants and antioxidants is a useful way to monitor antioxidant treatment.
非酒精性脂肪性肝病（NAFLD）是一个全球性的公共卫生问题，可导致肝脏相关的发病率和死亡率。它也是非传染性疾病的一个独立危险因素。2020年，有人提议将其称为“代谢功能障碍相关脂肪性肝病（MAFLD）”，并给出了简明的诊断标准。鉴于其广泛存在，其治疗至关重要。氧化应激水平升高会引发这种疾病。本综述旨在评估关于MAFLD患者抗氧化治疗的各项研究。我们在PubMed、SCOPUS和ScienceDirect数据库中对相关研究进行了全面检索，共识别出87项符合纳入标准的研究。在人体研究中，总计31.1%使用天然抗氧化剂，53.3%使用合成抗氧化剂，15.5%同时使用天然和合成抗氧化剂。在基于人体的研究中，天然抗氧化剂对MAFLD的治疗显示出100%的疗效，而合成抗氧化剂仅在91%的研究中显示出有效结果。在基于动物的研究中，天然抗氧化剂对MAFLD的治疗完全有效，而合成抗氧化剂仅在87.8%的评估中显示出有效性。总之，天然形式的抗氧化剂对MAFLD患者更有帮助，维持促氧化剂和抗氧化剂的正确平衡是监测抗氧化治疗的一种有用方法。
