Shea S A, Benchetrit G, Pham Dinh T, Hamilton R D, Guz A
Department of Medicine, Charing Cross and Westminster Medical School, London, UK.
Respir Physiol. 1989 Feb;75(2):211-23. doi: 10.1016/0034-5687(89)90065-0.
The resting breathing patterns of healthy adult identical twins were compared to see if there was any possible genetic component in the determination of this pattern. From breath-by-breath analysis of airflow, measured with a pneumotachometer (9 pairs of twins), the pattern of breathing was quantified in terms of individual respiratory variables; inspiratory time (TI), expiratory time (TE), total breath duration (TTOT), VT/TI, TI/TTOT, and by taking TI, TE and VT all together (TRIAD). Also, the airflow shape was quantified by harmonic analysis (ASTER). A second study was performed under more strictly defined conditions of rest and where the respiratory variables were estimated with respiratory inductance plethysmography to eliminate the possible effect of a facemask (5 pairs of twins). In each study, for each variable, the differences within twin-pairs were compared to the differences within random-pairs from the same subject population. In both studies, there were highly significant similarities within twin-pairs in the pattern of breathing, being best demonstrated when the entire 'shape' of the pneumotachogram (ASTER) or the spirogram (TRIAD) was considered.
对健康成年同卵双胞胎的静息呼吸模式进行比较，以观察在这种模式的决定因素中是否存在任何可能的遗传成分。通过用呼吸速度计测量气流的逐次呼吸分析（9对双胞胎），根据个体呼吸变量对呼吸模式进行量化；吸气时间（TI）、呼气时间（TE）、总呼吸持续时间（TTOT）、VT/TI、TI/TTOT，并将TI、TE和VT一起考虑（TRIAD）。此外，通过谐波分析（ASTER）对气流形状进行量化。第二项研究在更严格定义的静息条件下进行，并用呼吸感应体积描记法估计呼吸变量，以消除面罩可能产生的影响（5对双胞胎）。在每项研究中，对于每个变量，将双胞胎对内部的差异与来自相同受试者群体的随机对内部的差异进行比较。在两项研究中，双胞胎对在呼吸模式上都有高度显著的相似性，当考虑呼吸速度描记图（ASTER）或呼吸描记图（TRIAD）的整个“形状”时，这种相似性表现得最为明显。
