Calabrese P, Dinh T P, Eberhard A, Bachy J P, Benchetrit G
Physiologie Respiratoire, Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, La Tronche, France.
Respir Physiol. 1998 Aug;113(2):167-79. doi: 10.1016/s0034-5687(98)00063-2.
In order to determine changes in breathing patterns brought about by resistive loading, ventilation was recorded in 11 healthy subjects with four linear resistances (3.57, 5.75, 8.76 and 13.13 cmH2O L(-1) sec) added in a random order throughout the entire breath. At steady state, a breath-by-breath analysis of airflow was used to quantify the pattern of breathing in terms of respiratory variables: TI, TE, Tt, VT, VT/TI, TI/Tt, and by taking TI, TE, VT all together (TRIAD) and also the shape of the entire airflow profile quantified by harmonic analysis (ASTER). Group analysis using ANOVA showed significant changes in all variables. There were increasing changes with increasing loads in all variables, the smallest changes being in TI/Tt. Within to between-individual comparisons between two loads showed that only TI/Tt and the ASTER were more similar within than between-individuals for all comparisons. It was concluded that at steady state mechanisms of load compensation come into play inducing changes in the pattern of breathing proportional to the loads while maintaining some of the individual characteristics.
为了确定由阻力负荷引起的呼吸模式变化，在11名健康受试者中记录了通气情况，在整个呼吸过程中以随机顺序添加了四种线性阻力（3.57、5.75、8.76和13.13 cmH2O L(-1) sec）。在稳定状态下，对气流进行逐次呼吸分析，以根据呼吸变量TI、TE、Tt、VT、VT/TI、TI/Tt来量化呼吸模式，并通过将TI、TE、VT综合起来（TRIAD）以及通过谐波分析量化整个气流轮廓的形状（ASTER）。使用方差分析的组分析显示所有变量都有显著变化。所有变量都随着负荷增加而有增加的变化，TI/Tt的变化最小。在两个负荷之间的个体内与个体间比较表明，在所有比较中，只有TI/Tt和ASTER在个体内比个体间更相似。得出的结论是，在稳定状态下，负荷补偿机制发挥作用，导致呼吸模式的变化与负荷成比例，同时保持一些个体特征。
