MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Spemannstrasse 41, 72076, Tübingen, Germany.
Angew Chem Int Ed Engl. 2016 Jun 13;55(25):7038-46. doi: 10.1002/anie.201510956. Epub 2016 Apr 26.
Bioresponsive MRI contrast agents hold great promise for monitoring major physiological and pathological processes in a non-invasive manner. They are capable of altering the acquired MRI signal as a consequence of changes in their microenvironment, thus allowing real-time functional reporting in living organisms. Importantly, chemistry offers diverse solutions for the design of agents which respond to a great number of specific targets. However, the path to the successful utilization of these biomarkers in the desired functional MRI studies involves careful consideration of multiple scientific, technical, and practical issues across various research disciplines. This Minireview highlights the critical steps for planning and executing such multidisciplinary projects with an aim to substantially improve our knowledge of essential biological processes.
生物响应性 MRI 对比剂在非侵入性方式监测主要生理和病理过程方面具有巨大的应用前景。它们能够改变其微环境引起的 MRI 信号，从而允许在活体中进行实时功能报告。重要的是，化学为设计响应大量特定靶标的试剂提供了多种解决方案。然而，要想成功地将这些生物标志物应用于所需的功能 MRI 研究中，需要仔细考虑多个科学、技术和实际问题，涉及多个研究领域。本综述强调了规划和执行此类多学科项目的关键步骤，旨在大大提高我们对基本生物过程的认识。
