College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China.
College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China.
Carbohydr Polym. 2016 Aug 1;146:427-34. doi: 10.1016/j.carbpol.2016.03.002. Epub 2016 Mar 7.
Chitosan (CS)/gelatin (Gel)/polyvinyl alcohol (PVA) hydrogels were prepared by the gamma irradiation method for usage in wound dressing applications. Chitosan and gelatin solution was mixed with poly(vinyl alcohol) (PVA) solution at different weight ratios of CS/Gel of 1:3, 1:2, 1:1, 2:1 and 3:1. The hydrogels irradiated at 40kGy. The structure of the hydrogels was characterized by using FT-IR and SEM. The CS/Gel/PVA hydrogels were characterized for physical properties and blood clotting activity. The tensile strength of CS/Gel/PVA hydrogel enhanced than on the basis of the Gel/PVA hydrogel. The highest tensile strength reached the 2.2Mpa. All hydrogels have shown a good coagulation effect. It takes only 5min for the BCI index to reached 0.032 only 5min when the weight ratio of CS/Gel was 1:1. It means that the hemostatic effect of hydrogels were optimal. And the hydrogrls also showed good pH-sensitivity, swelling ability and water evaporation rate. Therefore, this hydrogel showed a promising potential to be applied as wound dressing.
壳聚糖（CS）/明胶（Gel）/聚乙烯醇（PVA）水凝胶通过γ射线辐射法制备，用于伤口敷用。将壳聚糖和明胶溶液与聚乙烯醇（PVA）溶液以不同的 CS/Gel 重量比 1:3、1:2、1:1、2:1 和 3:1 混合。水凝胶在 40kGy 下辐照。使用傅里叶变换红外光谱（FT-IR）和扫描电子显微镜（SEM）对水凝胶的结构进行了表征。对 CS/Gel/PVA 水凝胶的物理性能和凝血活性进行了表征。CS/Gel/PVA 水凝胶的拉伸强度比 Gel/PVA 水凝胶增强。最高拉伸强度达到 2.2Mpa。所有水凝胶均显示出良好的凝血效果。当 CS/Gel 重量比为 1:1 时，BCI 指数仅需 5 分钟即可达到 0.032，仅需 5 分钟。这意味着水凝胶的止血效果最佳。而且水凝胶还表现出良好的 pH 敏感性、溶胀能力和水蒸发率。因此，这种水凝胶显示出作为伤口敷料的应用有很大的潜力。
