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蜂属蜂蜜减轻老龄大鼠噪声应激诱导的记忆缺陷。

Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats.

作者信息

Azman Khairunnuur Fairuz, Zakaria Rahimah, Abdul Aziz Che Badariah, Othman Zahiruddin

机构信息

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150 Kota Bharu, Kelantan, Malaysia.

Department of Psychiatry, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150 Kota Bharu, Kelantan, Malaysia.

出版信息

Oxid Med Cell Longev. 2016;2016:1549158. doi: 10.1155/2016/1549158. Epub 2016 Mar 28.

DOI:10.1155/2016/1549158
PMID:27119005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4826941/
Abstract

Ageing and stress exposure may lead to memory impairment while oxidative stress is thought to be one of the underlying mechanisms involved. This study aimed to investigate the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress. Tualang honey supplementation was given orally, 200 mg/kg body weight for 28 days. Rats in the stress group were subjected to loud noise, 100 dB(A), 4 hours daily for 14 days. All rats were subjected to novel object recognition test for evaluation of memory performance. It was observed that the rats subjected to noise stress exhibited significantly lower memory performance and higher oxidative stress as evident by elevated malondialdehyde and protein carbonyl levels and reduction of antioxidant enzymes activities compared to the nonstressed rats. Tualang honey supplementation was able to improve memory performance, decrease oxidative stress levels, increase brain-derived neurotrophic factor (BDNF) concentration, decrease acetylcholinesterase activity, and enhance neuronal proliferation in the medial prefrontal cortex (mPFC) and hippocampus. In conclusion, Tualang honey protects against memory decline due to stress exposure and/or ageing via enhancement of mPFC and hippocampal morphology possibly secondary to reduction in brain oxidative stress and/or upregulation of BDNF concentration and cholinergic system.

摘要

衰老和应激暴露可能导致记忆障碍，而氧化应激被认为是其中的潜在机制之一。本研究旨在探讨补充特琅蜂蜜对暴露于噪声应激的老年大鼠记忆表现的潜在保护作用。按200毫克/千克体重口服补充特琅蜂蜜，持续28天。应激组大鼠每天暴露于100分贝(A)的强噪声中4小时，持续14天。所有大鼠均接受新物体识别测试以评估记忆表现。观察到，与未受应激的大鼠相比，遭受噪声应激的大鼠表现出显著更低的记忆表现和更高的氧化应激，这可通过丙二醛和蛋白质羰基水平升高以及抗氧化酶活性降低得以证明。补充特琅蜂蜜能够改善记忆表现、降低氧化应激水平、增加脑源性神经营养因子(BDNF)浓度、降低乙酰胆碱酯酶活性，并增强内侧前额叶皮质(mPFC)和海马体中的神经元增殖。总之，特琅蜂蜜可通过增强mPFC和海马体形态来预防因应激暴露和/或衰老导致的记忆衰退，这可能继发于脑氧化应激的降低和/或BDNF浓度及胆碱能系统的上调。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/7af25d5dc5ae/OMCL2016-1549158.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/b04ffa2c1fd2/OMCL2016-1549158.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/069a1d7d217d/OMCL2016-1549158.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/c37e9f576934/OMCL2016-1549158.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/2040b723c909/OMCL2016-1549158.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/55371c1331da/OMCL2016-1549158.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/7af25d5dc5ae/OMCL2016-1549158.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/b04ffa2c1fd2/OMCL2016-1549158.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/069a1d7d217d/OMCL2016-1549158.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/c37e9f576934/OMCL2016-1549158.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/2040b723c909/OMCL2016-1549158.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/55371c1331da/OMCL2016-1549158.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdc7/4826941/7af25d5dc5ae/OMCL2016-1549158.006.jpg

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