正畸牙齿移动中的根尖外吸收与修复：生物学事件
Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events.
作者信息
Feller Liviu, Khammissa Razia A G, Thomadakis George, Fourie Jeanine, Lemmer Johan
机构信息
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Private Practice, 15 School Road, Corner Rivonia Road, Morningside, Johannesburg, South Africa.
出版信息
Biomed Res Int. 2016;2016:4864195. doi: 10.1155/2016/4864195. Epub 2016 Mar 29.
Abstract
Some degree of external root resorption is a frequent, unpredictable, and unavoidable consequence of orthodontic tooth movement mediated by odontoclasts/cementoclasts originating from circulating precursor cells in the periodontal ligament. Its pathogenesis involves mechanical forces initiating complex interactions between signalling pathways activated by various biological agents. Resorption of cementum is regulated by mechanisms similar to those controlling osteoclastogenesis and bone resorption. Following root resorption there is repair by cellular cementum, but factors mediating the transition from resorption to repair are not clear. In this paper we review some of the biological events associated with orthodontically induced external root resorption.
摘要
一定程度的外源性牙根吸收是由牙周膜中循环前体细胞产生的破牙细胞/破牙骨质细胞介导的正畸牙齿移动常见、不可预测且不可避免的后果。其发病机制涉及机械力引发各种生物因子激活的信号通路之间的复杂相互作用。牙骨质的吸收受与控制破骨细胞生成和骨吸收的机制相似的机制调节。牙根吸收后会由细胞性牙骨质进行修复，但介导从吸收到修复转变的因素尚不清楚。在本文中，我们综述了一些与正畸诱导的外源性牙根吸收相关的生物学事件。
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