Department of Pediatric Pulmonology and Pediatric Allergy, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
GRIAC Research Institute, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Allergy. 2016 Jul;71(7):1069-73. doi: 10.1111/all.12923. Epub 2016 May 10.
The time during which children are observed following a double-blind, placebo-controlled food challenge (DBPCFC) varies in clinical practice. There are little data on late reactions (LRs) following DBPCFCs. Therefore, we determined the prevalence, severity and clinical characteristics of late reactions in food-allergic children and adolescents after DBPCFC, and ascertained which factors are associated with, and may predict, LRs. Logistic regression analyses were performed to investigate which factors were associated with LRs and to develop the association and prediction models. A total of 1142 children underwent DBPCFCs (child-test combinations). Of these 1142 child-test combinations, 400 reported LRs following the DBPCFC. LRs in food-allergic children after DBPCFC are poorly predictable and are generally not severe. All LRs, including those on the placebo day, are more frequently reported in younger children. Children who do not experience severe immediate reactions may be safely discharged home 2 h after a DBPCFC.
在临床实践中，观察儿童进行双盲、安慰剂对照食物挑战（DBPCFC）的时间有所不同。关于 DBPCFC 后迟发反应（LRs）的数据很少。因此，我们确定了 DBPCFC 后食物过敏儿童和青少年迟发反应的患病率、严重程度和临床特征，并确定了与 LRs 相关并可能预测 LRs 的因素。进行了逻辑回归分析，以调查哪些因素与 LRs 相关，并制定关联和预测模型。共有 1142 名儿童接受了 DBPCFC（儿童-测试组合）。在这 1142 个儿童-测试组合中，有 400 个报告在 DBPCFC 后出现 LRs。DBPCFC 后食物过敏儿童的 LRs 预测性差，通常不严重。所有 LRs，包括安慰剂日的 LRs，在年龄较小的儿童中更频繁地报告。在 DBPCFC 后 2 小时内没有发生严重即刻反应的儿童可以安全出院回家。
