Azad Tej D, Veeravagu Anand, Steinberg Gary K
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California.
Neurosurg Focus. 2016 May;40(5):E2. doi: 10.3171/2016.2.FOCUS15637.
Recent advancements in stem cell biology and neuromodulation have ushered in a battery of new neurorestorative therapies for ischemic stroke. While the understanding of stroke pathophysiology has matured, the ability to restore patients' quality of life remains inadequate. New therapeutic approaches, including cell transplantation and neurostimulation, focus on reestablishing the circuits disrupted by ischemia through multidimensional mechanisms to improve neuroplasticity and remodeling. The authors provide a broad overview of stroke pathophysiology and existing therapies to highlight the scientific and clinical implications of neurorestorative therapies for stroke.
干细胞生物学和神经调节领域的最新进展带来了一系列用于缺血性中风的新型神经修复疗法。尽管对中风病理生理学的理解已经成熟,但恢复患者生活质量的能力仍然不足。包括细胞移植和神经刺激在内的新治疗方法,侧重于通过多维机制重建因缺血而中断的神经回路,以改善神经可塑性和重塑。作者对中风病理生理学和现有疗法进行了广泛概述,以突出神经修复疗法对中风的科学和临床意义。