Theodosis D T, Poulain D A
Unité de Recherches de Neurobiologie des Comportements, INSERM U.176, University of Bordeaux II, France.
Brain Res. 1989 Apr 10;484(1-2):361-6. doi: 10.1016/0006-8993(89)90382-x.
Using quantitative ultrastructural analysis on cells identified by immunogold postembedding immunocytochemistry, we show that magnocellular oxytocinergic neurons in the adult rat paraventricular nucleus (PVN) undergo significant neuronal-glial and synaptic changes upon stimulation. Thus, during lactation, the surface membranes of most PVN oxytocinergic somata and dendrites were directly juxtaposed; many were also contacted synaptically by the same axonal terminal ('shared' synapses). Non-oxytocinergic profiles showed few plasmalemma juxtapositions and 'shared' synapses. These ultrastructural changes are similar to those that modify oxytocin neurons in the supraoptic nucleus under the same conditions, and indicate that the whole oxytocinergic system in the hypothalamus is capable of neuronal-glial and synaptic plasticity when stimulated to release its neurohormone.
通过对经免疫金包埋后免疫细胞化学鉴定的细胞进行定量超微结构分析，我们发现成年大鼠室旁核（PVN）中的大细胞性催产素能神经元在受到刺激时会发生显著的神经-胶质和突触变化。因此，在哺乳期，大多数PVN催产素能神经元的胞体和树突的表面膜直接并列；许多还通过同一轴突终末发生突触联系（“共享”突触）。非催产素能细胞很少有质膜并列和“共享”突触。这些超微结构变化与在相同条件下对视上核中催产素神经元产生影响的变化相似，表明当下丘脑的整个催产素能系统被刺激释放其神经激素时，它具有神经-胶质和突触可塑性。
