Claustrat B, Loisy C, Brun J, Beorchia S, Arnaud J L, Chazot G
Headache. 1989 Apr;29(4):242-5. doi: 10.1111/j.1526-4610.1989.hed22904242.x.
We determined by radioimmunoassay plasma melatonin levels on blood samples drawn at 11 p.m. in migraine patients and control subjects. Ninety-three cephalalgic outpatients (75 females, 18 males) were compared to a control group (24 females, 22 males) matched according to age. Patients were divided into subgroups presenting common migraine (n = 38); ophthalmic migraine (n = 12); and tension headache associated with ophthalmic or common migraine (n = 24), and associated depressive status (n = 19). Statistical analysis revealed a decrease in plasma melatonin levels for the entire migraine population, compared to the control one, and a heterogeneity in both controls and patients; this heterogeneity was found mainly in the depressive and tension headache subgroups. When the migraine population--from which the depressive patients were excluded--was divided into male and female subgroups, a decrease in plasma melatonin levels was observed only for the female subgroups. Results are discussed with reference to the role of the pineal gland in the synchronization of the organism with the environmental conditions.
我们通过放射免疫分析法测定了偏头痛患者和对照受试者晚上11点采集的血样中的血浆褪黑素水平。93名头痛门诊患者（75名女性，18名男性）与根据年龄匹配的对照组（24名女性，22名男性）进行了比较。患者被分为普通偏头痛亚组（n = 38）；眼性偏头痛亚组（n = 12）；与眼性或普通偏头痛相关的紧张性头痛亚组（n = 24），以及伴有抑郁状态的亚组（n = 19）。统计分析显示，与对照组相比，整个偏头痛人群的血浆褪黑素水平降低，且对照组和患者组均存在异质性；这种异质性主要存在于抑郁和紧张性头痛亚组中。当排除抑郁患者后的偏头痛人群分为男性和女性亚组时，仅在女性亚组中观察到血浆褪黑素水平降低。本文结合松果体在机体与环境条件同步中的作用对结果进行了讨论。
