Claustrat B, Brun J, Geoffriau M, Zaidan R, Mallo C, Chazot G
Service de Radiopharmacie et Radioanalyse, Hôpital Neuro-Cardiologique, Lyon, France.
Cephalalgia. 1997 Jun;17(4):511-7; discussion 487. doi: 10.1046/j.1468-2982.1997.1704511.x.
The plasma melatonin profile was significantly disturbed (phase-shift of the maximum melatonin level) in four out of six female sufferers from status migrainosus, compared with nine healthy controls. The number of secretion peaks was similar in both groups. A nocturnal 20 micrograms melatonin infusion (from 21.00 to 01.00 h) evoked plasma melatonin levels slightly higher than a physiological secretion peak. During infusion, the episodes of secretion were reinforced and the endogenous plasma profile was phase-advanced in two patients displaying a phase-delay. These data suggest impaired pineal function in migraine. In the absence of side effects of melatonin infusion, the relief of certain migraine symptoms described by our patients might support a controlled trial of melatonin in migraine.
与9名健康对照者相比，6名偏头痛持续状态女性患者中有4名的血浆褪黑素水平曲线受到显著干扰（褪黑素水平最大值出现相移）。两组的分泌峰数量相似。夜间输注20微克褪黑素（从21:00至01:00）引起的血浆褪黑素水平略高于生理性分泌峰。在输注过程中，两名表现为相位延迟的患者的分泌发作得到增强，内源性血浆水平曲线出现相位提前。这些数据表明偏头痛患者的松果体功能受损。由于褪黑素输注没有副作用，我们的患者描述的某些偏头痛症状得到缓解，这可能支持对偏头痛患者进行褪黑素对照试验。
