Botelho Ana M N, Costa Maiana O C, Beltrame Cristiana O, Ferreira Fabienne A, Côrtes Marina F, Bandeira Paula T, Lima Nicholas C B, Souza Rangel C, Almeida Luiz G P, Vasconcelos Ana T R, Nicolás Marisa F, Figueiredo Agnes M S
Laboratório de Biologia Molecular de Bactérias, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902 RJ Brazil.
Laboratório Nacional de Computação Científica, Petrópolis, 25651-075 RJ Brazil.
Stand Genomic Sci. 2016 May 4;11:34. doi: 10.1186/s40793-016-0154-x. eCollection 2016.
Staphylococcus aureus is a versatile Gram-positive coccus frequently found colonizing the skin and nasal membranes of humans. The acquisition of the staphylococcal cassette chromosome mec was a major milestone in the evolutionary path of methicillin-resistant S. aureus. This genetic element carries the mecA gene, the main determinant of methicillin resistance. MRSA is involved in a plethora of opportunistic infectious diseases. The accessory gene regulator is the major S. aureus quorum sensing system, playing an important role in staphylococcal virulence, including the development of biofilms. We report the complete genome sequence (NCBI BioProject ID: PRJNA264181) of the methicillin-resistant S. aureus strain GV69 (= CMVRS P4521), a variant of the ST239 lineage that presents with a natural attenuation of agr-RNAIII transcription and a moderate accumulation of biofilm.
金黄色葡萄球菌是一种常见的革兰氏阳性球菌，经常在人类的皮肤和鼻黏膜中定植。葡萄球菌盒式染色体mec的获得是耐甲氧西林金黄色葡萄球菌进化过程中的一个重要里程碑。这个遗传元件携带mecA基因，它是耐甲氧西林的主要决定因素。耐甲氧西林金黄色葡萄球菌涉及多种机会性传染病。辅助基因调节因子是金黄色葡萄球菌的主要群体感应系统，在葡萄球菌毒力（包括生物膜的形成）中起重要作用。我们报告了耐甲氧西林金黄色葡萄球菌菌株GV69（= CMVRS P4521）的完整基因组序列（NCBI生物项目编号：PRJNA264181），它是ST239谱系的一个变体，表现出agr - RNAIII转录的自然衰减和生物膜的适度积累。
