Gould J F, Anderson A J, Yelland L N, Gibson R A, Makrides M
Women's and Children's Health Research Institute, 72 King William Road, North Adelaide, Australia; South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.
Women's and Children's Health Research Institute, 72 King William Road, North Adelaide, Australia; South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia; School of Public Health, University of Adelaide, Adelaide, Australia.
Prostaglandins Leukot Essent Fatty Acids. 2016 May;108:5-12. doi: 10.1016/j.plefa.2016.03.011. Epub 2016 Mar 23.
We explored the degree to which maternal and offspring outcomes resulting from consuming prenatal docosahexaenoic acid (DHA, 800mg/day) in a clinical trial were influenced by maternal characteristics. Among non-smokers, women who received DHA had heavier babies (adjusted mean difference (MD)=99g 95% CI 45-153, p<0.01; interaction p=0.01) and fewer low birth weight babies than control women (adjusted relative risk=0.43 95% CI 0.25-0.74, p<0.01; interaction p=0.01). From women who had not completed further education, children in the DHA group had higher cognitive scores at 18 months compared with control children (adjusted MD=3.15 95% CI 0.93-5.37, p=0.01; interaction p<0.01). Conversely, the children of women who completed further education in the DHA group had lower language scores than control children (adjusted MD -2.82 95% CI -4.90 to -0.73, p=0.01; interaction p=0.04). Our results support the notion that responsiveness to prenatal DHA may depend on the characteristics of specific population subgroups.
我们探讨了在一项临床试验中，孕妇摄入产前二十二碳六烯酸（DHA，800毫克/天）所产生的母婴结局受孕妇特征影响的程度。在不吸烟的女性中，摄入DHA的女性所生婴儿体重更重（调整后平均差（MD）=99克，95%置信区间45 - 153，p<0.01；交互作用p=0.01），且低出生体重婴儿比对照组女性少（调整后相对风险=0.43，95%置信区间0.25 - 0.74，p<0.01；交互作用p=0.01）。在未完成继续教育的女性中，DHA组儿童在18个月时的认知得分高于对照组儿童（调整后MD=3.15，95%置信区间0.93 - 5.37，p=0.01；交互作用p<0.01）。相反，在完成继续教育的女性中，DHA组儿童的语言得分低于对照组儿童（调整后MD=-2.82，95%置信区间-4.90至-0.73，p=0.01；交互作用p=0.04）。我们的结果支持这样一种观点，即对产前DHA的反应性可能取决于特定人群亚组的特征。
