Snapp K R, Boyer D B, Peterson L C, Svare C W
Department of Prosthodontics, College of Dentistry, University of Iowa, Iowa City 52242.
J Dent Res. 1989 May;68(5):780-5. doi: 10.1177/00220345890680050501.
We determined the exposure to mercury from dental amalgam by comparison of blood levels of mercury before and after removal of all amalgams from ten subjects. Baseline concentrations of mercury in whole blood were measured weekly for four to 18 weeks (median = 6.6 weeks) prior to removal. All amalgams were removed in a single appointment. The subjects had an average of 14 surfaces of amalgam, seven of which were occlusal surfaces. Weekly blood sampling was continued for five to 18 weeks (median = 7.6 weeks) after the amalgams were removed. The mean baseline concentration of total mercury in whole blood of the ten subjects was 2.18 (SD = 0.90) ng Hg/mL before the amalgams were removed. The baseline mercury levels were related to the number of amalgam surfaces. The linear correlation coefficient was 0.724 with number of occlusal surfaces, and 0.433 with total number of surfaces. After removal of the amalgams, nine of the ten subjects exhibited a statistically significant decrease in blood mercury at the 95% level of confidence. The mean decrease in mercury was 1.13 (SD = 0.60) ng Hg/mL. The half-time for elimination of mercury from blood after amalgam removal was 30.2 (SD = 5.8) days. Removal of the amalgams provided an additional exposure of 1.46 (SD = 1.17) ng Hg/mL that was rapidly cleared from the blood with a half-time of 2.9 days. The daily intake of mercury from amalgam in the subjects was estimated to be at least 1.3 micrograms.
我们通过比较十名受试者全部汞合金填充物移除前后的血液汞含量，来确定汞合金填充物导致的汞暴露情况。在移除汞合金填充物之前，连续四至十八周（中位数为6.6周）每周测量全血汞的基线浓度。所有汞合金填充物在一次就诊时全部移除。受试者平均有14个汞合金表面，其中7个为咬合面。在移除汞合金填充物后，继续每周进行血液采样五至十八周（中位数为7.6周）。在移除汞合金填充物之前，这十名受试者全血中总汞的平均基线浓度为2.18（标准差 = 0.90）纳克汞/毫升。基线汞水平与汞合金表面数量有关。与咬合面数量的线性相关系数为0.724，与总表面数量的线性相关系数为0.433。移除汞合金填充物后，十名受试者中有九名在95%置信水平下血液汞含量出现统计学显著下降。汞含量的平均下降值为1.13（标准差 = 0.60）纳克汞/毫升。移除汞合金填充物后，血液中汞的消除半衰期为30.2（标准差 = 5.8）天。移除汞合金填充物导致额外的汞暴露量为1.46（标准差 = 1.17）纳克汞/毫升，且从血液中快速清除，半衰期为2.9天。估计受试者从汞合金填充物中每日摄入的汞至少为1.3微克。
