Grümayer E R, Panzer S, Ferenci P, Gadner H
St. Anna Children's Hospital, Vienna, Austria.
J Hepatol. 1989 Mar;8(2):232-5. doi: 10.1016/0168-8278(89)90012-3.
Two patients showed an unusual serologic response to hepatitis B virus infection during intensive chemotherapy for acute lymphoblastic leukemia. Before treatment, one patient was anti-HBs- and anti-HBc-positive. During intensive chemotherapy these antibodies disappeared and HBsAg and HBeAg became detectable. Twenty months later, still on maintenance chemotherapy, active viral replication with high DNA polymerase levels was present. The second patient developed anti-HBc during the first course of intensive chemotherapy for acute lymphoblastic leukemia. She had anti-HBc and anti-HBe when a bone marrow relapse of the leukemia was diagnosed 3 years later and became HBsAg-positive together with high DNA polymerase levels in the serum while receiving intensive chemotherapy. Clinically no signs of active hepatitis were noted in these patients.
两名急性淋巴细胞白血病患者在强化化疗期间对乙型肝炎病毒感染呈现出异常的血清学反应。治疗前，一名患者抗-HBs和抗-HBc呈阳性。在强化化疗期间，这些抗体消失，HBsAg和HBeAg变得可检测到。20个月后，仍在进行维持化疗时，出现了高DNA聚合酶水平的活跃病毒复制。第二名患者在急性淋巴细胞白血病强化化疗的第一个疗程中出现了抗-HBc。3年后诊断出白血病骨髓复发时，她有抗-HBc和抗-HBe，在接受强化化疗期间血清中HBsAg呈阳性且DNA聚合酶水平升高。临床上这些患者未出现活动性肝炎的迹象。
