• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种引人入胜的方法，即通过绿色合成的芦丁模板介孔硅纳米粒子负载纳米银来实现抗菌活性。

An intriguing approach toward antibacterial activity of green synthesized Rutin-templated mesoporous silica nanoparticles decorated with nanosilver.

机构信息

Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.

Department of Materials Science and Engineering, Shiraz University of Technology, Shiraz, Iran.

出版信息

Sci Rep. 2023 Apr 12;13(1):5987. doi: 10.1038/s41598-023-33095-1.

DOI:10.1038/s41598-023-33095-1
PMID:37046068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10097644/
Abstract

In recent years, mesoporous silica nanoparticles (MSNs) have been applied in various biomedicine fields like bioimaging, drug delivery, and antibacterial alternatives. MSNs could be manufactured through green synthetic methods as environmentally friendly and sustainable synthesis approaches, to improve physiochemical characteristics for biomedical applications. In the present research, we used Rutin (Ru) extract, a biocompatible flavonoid, as the reducing agent and nonsurfactant template for the green synthesis of Ag-decorated MSNs. Transmission electron microscopy (TEM), zeta-potential, x-ray powder diffraction (XRD), fourier transform infrared (FTIR) spectroscopy analysis, scanning electron microscopy (SEM), brunauer-emmett-teller (BET) analysis, and energy-dispersive system (EDS) spectroscopy were used to evaluate the Ag-decorated MSNs physical characteristics. The antimicrobial properties were evaluated against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and also different types of candida. The cytotoxicity test was performed by using the MTT assay. Based on the findings, the significant antimicrobial efficacy of Ru-Ag-decorated MSNs against both gram positive and gram negative bacteria and different types of fungi was detected as well as acceptable safety and low cytotoxicity even at lower concentrations. Our results have given a straightforward and cost-effective method for fabricating biodegradable Ag-decorated MSNs. The applications of these MSNs in the domains of biomedicine appear to be promising.

摘要

近年来，介孔硅纳米粒子（MSNs）已应用于生物成像、药物输送和抗菌替代品等多个生物医药领域。MSNs 可以通过绿色合成方法制造，作为环保和可持续的合成方法，以改善用于生物医学应用的物理化学特性。在本研究中，我们使用芦丁（Ru）提取物，一种生物相容性的类黄酮，作为绿色合成 Ag 修饰的 MSNs 的还原剂和非表面活性剂模板。透射电子显微镜（TEM）、zeta 电位、X 射线粉末衍射（XRD）、傅里叶变换红外（FTIR）光谱分析、扫描电子显微镜（SEM）、BET 分析和能谱（EDS）光谱用于评估 Ag 修饰的 MSNs 的物理特性。评估了其对金黄色葡萄球菌（S. aureus）、大肠杆菌（E. coli）以及不同类型念珠菌的抗菌性能。通过 MTT 测定法进行了细胞毒性试验。根据研究结果，发现 Ru-Ag 修饰的 MSNs 对革兰氏阳性菌和革兰氏阴性菌以及不同类型真菌均具有显著的抗菌功效，而且即使在较低浓度下，安全性也可接受，细胞毒性也较低。我们的结果提供了一种简单且经济高效的方法来制造可生物降解的 Ag 修饰的 MSNs。这些 MSNs 在生物医学领域的应用似乎很有前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/afdc1ab23756/41598_2023_33095_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/3aaf70ce9d0a/41598_2023_33095_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/82fc2eacf0e5/41598_2023_33095_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/bc3a1991aa84/41598_2023_33095_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/6770cf5a7776/41598_2023_33095_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/32ab3f45091e/41598_2023_33095_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/b978eb59a5f1/41598_2023_33095_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/afdc1ab23756/41598_2023_33095_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/3aaf70ce9d0a/41598_2023_33095_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/82fc2eacf0e5/41598_2023_33095_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/bc3a1991aa84/41598_2023_33095_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/6770cf5a7776/41598_2023_33095_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/32ab3f45091e/41598_2023_33095_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/b978eb59a5f1/41598_2023_33095_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d8d/10097644/afdc1ab23756/41598_2023_33095_Fig7_HTML.jpg

相似文献

1
An intriguing approach toward antibacterial activity of green synthesized Rutin-templated mesoporous silica nanoparticles decorated with nanosilver.一种引人入胜的方法，即通过绿色合成的芦丁模板介孔硅纳米粒子负载纳米银来实现抗菌活性。
Sci Rep. 2023 Apr 12;13(1):5987. doi: 10.1038/s41598-023-33095-1.
2
Antibacterial and biodegradable tissue nano-adhesives for rapid wound closure.用于快速伤口闭合的抗菌和可生物降解的组织纳米粘合剂。
Int J Nanomedicine. 2018 Sep 27;13:5849-5863. doi: 10.2147/IJN.S177109. eCollection 2018.
3
Facile, one-pot synthesis, and antibacterial activity of mesoporous silica nanoparticles decorated with well-dispersed silver nanoparticles.介孔硅纳米粒子负载高度分散的银纳米粒子的简便一锅法合成及其抗菌活性。
ACS Appl Mater Interfaces. 2014 Aug 13;6(15):12038-45. doi: 10.1021/am5026424. Epub 2014 Jul 29.
4
Boosting antibacterial activity with mesoporous silica nanoparticles supported silver nanoclusters.介孔硅纳米粒子负载银纳米簇提高抗菌活性。
J Colloid Interface Sci. 2019 Nov 1;555:470-479. doi: 10.1016/j.jcis.2019.08.009. Epub 2019 Aug 3.
5
Construction of selenium-embedded mesoporous silica with improved antibacterial activity.具有增强抗菌活性的硒嵌入介孔二氧化硅的构建
Colloids Surf B Biointerfaces. 2020 Jun;190:110910. doi: 10.1016/j.colsurfb.2020.110910. Epub 2020 Feb 26.
6
Mesoporous silica nanoparticles decorated with polycationic dendrimers for infection treatment.介孔硅纳米粒子用阳离子树状聚合物进行修饰，用于感染治疗。
Acta Biomater. 2018 Mar 1;68:261-271. doi: 10.1016/j.actbio.2017.12.041. Epub 2018 Jan 5.
7
Janus silver mesoporous silica nanobullets with synergistic antibacterial functions.具有协同抗菌功能的Janus银介孔二氧化硅纳米子弹头
Colloids Surf B Biointerfaces. 2017 Sep 1;157:199-206. doi: 10.1016/j.colsurfb.2017.05.079. Epub 2017 Jun 4.
8
Antimicrobial activity of ZnO-Ag-MWCNTs nanocomposites prepared by a simple impregnation-calcination method.采用简单浸渍-煅烧法制备的 ZnO-Ag-MWCNTs 纳米复合材料的抗菌活性。
Sci Rep. 2023 Dec 5;13(1):21418. doi: 10.1038/s41598-023-48831-w.
9
Mycogenic Synthesis of Extracellular Zinc Oxide Nanoparticles from and Its Nanoantibiotic Potential.从 中合成细胞外氧化锌纳米粒子及其纳米抗生素潜力的真菌合成。
Int J Nanomedicine. 2020 Nov 2;15:8519-8536. doi: 10.2147/IJN.S271743. eCollection 2020.
10
In vivo antimicrobial activity of silver nanoparticles produced via a green chemistry synthesis using as a reducing and capping agent.采用绿色化学合成法，使用 作为还原剂和稳定剂制备的银纳米粒子的体内抗菌活性。
Int J Nanomedicine. 2018 Apr 17;13:2349-2363. doi: 10.2147/IJN.S160605. eCollection 2018.

引用本文的文献

1
Tackling carbapenem-resistant (CRAB) and their virulence factors using biosynthesized silver nanoparticles combined with imipenem.使用生物合成的银纳米颗粒与亚胺培南联合应对耐碳青霉烯类鲍曼不动杆菌（CRAB）及其毒力因子。
Biotechnol Notes. 2025 Jul 19;6:183-195. doi: 10.1016/j.biotno.2025.07.002. eCollection 2025.
2
Topical Delivery Systems for Plant-Derived Antimicrobial Agents: A Review of Current Advances.植物源抗菌剂的局部给药系统：当前进展综述
Int J Biomater. 2025 Jul 27;2025:4251091. doi: 10.1155/ijbm/4251091. eCollection 2025.
3
Comparative pharmacological studies on novel green-synthesized nano-zero-valent aluminum.

本文引用的文献

1
Antiviral and antioxidant properties of green synthesized gold nanoparticles using leaf extract.利用树叶提取物绿色合成金纳米粒子的抗病毒和抗氧化特性
Appl Nanosci. 2023;13(6):4395-4405. doi: 10.1007/s13204-022-02705-1. Epub 2022 Nov 27.
2
Nanotechnology Advances in the Detection and Treatment of Cancer: An Overview.纳米技术在癌症检测和治疗中的应用进展：概述。
Nanotheranostics. 2022 Aug 21;6(4):400-423. doi: 10.7150/ntno.74613. eCollection 2022.
3
Co-Delivery of Nano-Silver and Vancomycin via Silica Nanopollens for Enhanced Antibacterial Functions.
新型绿色合成纳米零价铝的比较药理学研究
RSC Adv. 2025 Jul 3;15(28):22807-22823. doi: 10.1039/d5ra03179f. eCollection 2025 Jun 30.
4
Optimization of Metal-Based Nanoparticle Composite Formulations and Their Application in Wound Dressings.金属基纳米颗粒复合配方的优化及其在伤口敷料中的应用。
Int J Nanomedicine. 2025 Mar 6;20:2813-2846. doi: 10.2147/IJN.S508036. eCollection 2025.
5
Development of a Carvedilol-Loaded Solid Self-Nanoemulsifying System with Increased Solubility and Bioavailability Using Mesoporous Silica Nanoparticles.使用介孔二氧化硅纳米颗粒开发具有更高溶解度和生物利用度的载卡维地洛固体自纳米乳化系统。
Int J Mol Sci. 2025 Feb 13;26(4):1592. doi: 10.3390/ijms26041592.
6
Antimicrobial Feature of Nanoparticles in the Antibiotic Resistance Era: From Mechanism to Application.抗生素耐药时代纳米颗粒的抗菌特性：从作用机制到应用
Adv Biomed Res. 2024 Nov 30;13:113. doi: 10.4103/abr.abr_92_24. eCollection 2024.
7
The enhanced antibacterial and antibiofilm properties of titanium dioxide nanoparticles biosynthesized by multidrug-resistant Pseudomonas aeruginosa.多重耐药铜绿假单胞菌生物合成的二氧化钛纳米颗粒增强的抗菌和抗生物膜特性。
BMC Microbiol. 2024 Oct 1;24(1):379. doi: 10.1186/s12866-024-03530-y.
8
L. peel extract-bioinspired anisotropic nano-silver with the multipurpose of hydrogenation eco-catalyst and antimicrobial resistance.荔枝果皮提取物仿生各向异性纳米银，具有氢化生态催化剂和抗微生物耐药性的多种用途。
Heliyon. 2024 Aug 8;10(16):e36037. doi: 10.1016/j.heliyon.2024.e36037. eCollection 2024 Aug 30.
9
ULK1 Mediated Autophagy-Promoting Effects of Rutin-Loaded Chitosan Nanoparticles Contribute to the Activation of NF-κB Signaling Besides Inhibiting EMT in Hep3B Hepatoma Cells.芦丁载壳聚糖纳米粒通过 ULK1 介导的自噬促进作用激活 NF-κB 信号通路，抑制 Hep3B 肝癌细胞 EMT。
Int J Nanomedicine. 2024 May 18;19:4465-4493. doi: 10.2147/IJN.S443117. eCollection 2024.
10
Synergistic effect of Silver-Nanodiamond composite as an efficient antibacterial agent against and .银-纳米金刚石复合材料作为一种高效抗菌剂对……和……的协同效应 。 （你提供的原文中“against”后面缺少具体对象，我按照字面意思翻译了，你可以补充完整信息以便我给出更准确的译文。）
Heliyon. 2024 May 3;10(9):e30500. doi: 10.1016/j.heliyon.2024.e30500. eCollection 2024 May 15.
通过二氧化硅纳米花粉共递送纳米银和万古霉素以增强抗菌功能。
Antibiotics (Basel). 2022 May 18;11(5):685. doi: 10.3390/antibiotics11050685.
4
In Vitro Evaluation of Antibacterial, Antioxidant, and Antidiabetic Activities and Glucose Uptake through 2-NBDG by Hep-2 Liver Cancer Cells Treated with Green Synthesized Silver Nanoparticles.绿原酸合成银纳米粒子对 Hep-2 肝癌细胞的体外抗菌、抗氧化、抗糖尿病活性及 2-NBDG 摄取的影响
Oxid Med Cell Longev. 2022 May 17;2022:1646687. doi: 10.1155/2022/1646687. eCollection 2022.
5
Self-propelled micro/nanobots: A new insight into precisely targeting cancerous cells through intelligent and deep cancer penetration.自主式微/纳米机器人：通过智能和深入的癌症穿透，精确靶向癌细胞的新视角。
Eur J Pharmacol. 2022 Jul 5;926:175011. doi: 10.1016/j.ejphar.2022.175011. Epub 2022 May 11.
6
Antibacterial activity and characteristics of silver nanoparticles biosynthesized from Carduus crispus.从蓟中生物合成的银纳米粒子的抗菌活性和特性。
Sci Rep. 2021 Oct 26;11(1):21047. doi: 10.1038/s41598-021-00520-2.
7
Synthesis of silver nanoparticles using Plantago lanceolata extract and assessing their antibacterial and antioxidant activities.利用车前草提取物合成银纳米粒子并评估其抗菌和抗氧化活性。
Sci Rep. 2021 Oct 21;11(1):20754. doi: 10.1038/s41598-021-00296-5.
8
Rutin: A Flavonoid as an Effective Sensitizer for Anticancer Therapy; Insights into Multifaceted Mechanisms and Applicability for Combination Therapy.芦丁：一种作为抗癌治疗有效敏化剂的类黄酮；对多方面机制及联合治疗适用性的见解
Evid Based Complement Alternat Med. 2021 Aug 23;2021:9913179. doi: 10.1155/2021/9913179. eCollection 2021.
9
Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19.具有免疫调节活性的药用植物和分离分子可作为包括 COVID-19 在内的病毒疾病的潜在替代疗法。
Front Immunol. 2021 May 13;12:637553. doi: 10.3389/fimmu.2021.637553. eCollection 2021.
10
Green synthesis of silver nanoparticles using Lysiloma acapulcensis exhibit high-antimicrobial activity.利用 Lysiloma acapulcensis 进行银纳米粒子的绿色合成表现出高抗菌活性。
Sci Rep. 2020 Jul 30;10(1):12805. doi: 10.1038/s41598-020-69606-7.