Ahmed Madiha, Phul Abdul Rehman, Haq Ihsan-ul, Bibi Gulnaz, Mazhar Kehkashan, Rehman Tofeequr, Zia Muhammad, Mirza Bushra
Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Pak J Pharm Sci. 2016 May;29(3):895-902.
Bergenia ciliata (locally known as Zakhm-e-hayat; wound healer) is commonly employed for wound healing, curing diarrhea and vomiting, fever, cough and pulmonary affections. Local community uses this plant as tea decoction with table salt. B. ciliata crude extract and its fractions were subjected to antibacterial, antioxidant effects as well as determination of total flavonoids and phenolics, DNA damage and anticancerous activities following standard protocols. Increased percentage inhibition of free radical in DPPH assay as well as elevated phenolic and flavonoid contents revealed antioxidant potential of this potent herb. Ethyl acetate and aqueous extracts showed IC(50) of 0.7 and 0.3 mg/ml respectively, against H157 cell line. Antibacterial analysis showed MIC 0.4-10mg/ml for crude extract and fractions. The results obtained conclude that extracts of B. ciliata contain remedial latent and can be used as possible source for drug development by pharmaceutical industries.
岩白菜（当地称为Zakhm - e - hayat；伤口愈合剂）通常用于伤口愈合、治疗腹泻和呕吐、发烧、咳嗽及肺部疾病。当地社区将这种植物与食盐一起作为茶煎剂使用。按照标准方案，对岩白菜粗提物及其馏分进行了抗菌、抗氧化作用以及总黄酮和酚类物质的测定、DNA损伤和抗癌活性研究。在DPPH试验中自由基抑制百分比的增加以及酚类和黄酮类含量的升高揭示了这种强效草药的抗氧化潜力。乙酸乙酯提取物和水提取物对H157细胞系的IC50分别为0.7和0.3 mg/ml。抗菌分析表明粗提物及其馏分的MIC为0.4 - 10mg/ml。所得结果表明，岩白菜提取物具有治疗潜力，可作为制药行业药物开发的可能来源。
