Horowitz H S, Heifetz S B, Poulsen S
J Am Dent Assoc. 1977 Dec;95(6):1133-9. doi: 10.14219/jada.archive.1977.0201.
The single application of a BIS-GMA adhesive sealant in Kalispell on a paired half-moouth basis and the annual monitoring of the sealed sites for five years is not a recommended preventive regimen. The study does proved information on the potential long-term in vivo retention of the sealant and its ability to prevent dental caries. The findings of this study clearly show that when this pit and fissure sealant is retained, its is effective in preventing caries in sealed tooth surfaces. Moreover, on occlusal surfaces, the usual susceptibility to decay is not altered by having been treated with a sealant that is not retained.
在蒙大拿州卡利斯佩尔对成对的半口牙齿单次应用双酚 A 缩水甘油醚甲基丙烯酸酯（BIS-GMA）粘结性封闭剂，并对封闭部位进行为期五年的年度监测，这不是一种推荐的预防方案。该研究确实提供了关于封闭剂在体内潜在长期留存情况及其预防龋齿能力的信息。这项研究的结果清楚地表明，当这种窝沟封闭剂留存时，它能有效预防封闭牙面的龋齿。此外，在咬合面上，未留存的封闭剂治疗并不会改变通常的龋齿易感性。
