Poulsen S, Thylstrup A, Christensen P F
Community Dent Oral Epidemiol. 1979 Jun;7(3):154-7. doi: 10.1111/j.1600-0528.1979.tb01205.x.
The aim of the present study was to test the caries-preventive effect of a bis-GMA type fissure sealant (Concise Enamel Bond System) in a public dental health service for children. The study compared one group of children, in which all sound permanent teeth were sealed, and a control group in which no sealants were placed. During the study period all children received systematic restorative care, while sealing was performed on the basis of diagnoses made at subsequent examinations by one of the authors. After 2 years a total of 187 children were available for re-examination. Sealant retention was comparable to that obtained in previous studies, but no statistically significant reduction in overall caries increment could be demonstrated. Further analysis showed that only 223 sites had been sealed, while the majority of all erupting sites (394) were either carious or filled before they were screened for the purpose of sealing. It is therefore assumed that only teeth less susceptible to occlusal decay were sealed, thereby explaining the lack of benefit derived from the sealing program.
本研究的目的是在儿童公共牙科保健服务中测试一种双甲基丙烯酸缩水甘油酯类窝沟封闭剂（Concise Enamel Bond System）的防龋效果。该研究比较了两组儿童，一组是所有健康恒牙均进行了窝沟封闭的儿童，另一组是未使用封闭剂的对照组。在研究期间，所有儿童均接受了系统的修复治疗，而窝沟封闭是根据其中一位作者在后续检查中做出的诊断进行的。2年后，共有187名儿童可供重新检查。封闭剂的保留情况与先前研究中获得的结果相当，但总体龋损增加量没有统计学上的显著降低。进一步分析表明，仅对223个部位进行了封闭，而在为封闭目的进行筛查之前，所有萌出部位中的大多数（394个）已患龋或已充填。因此推测，仅对不易发生咬合面龋的牙齿进行了封闭，从而解释了封闭计划未取得益处的原因。
