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Clinical trials: The mathematics of falling vaccine efficacy with rising disease incidence.

作者信息

Gomes M Gabriela M, Gordon Stephen B, Lalloo David G

机构信息

Liverpool School of Tropical Medicine, United Kingdom; CIBIO-InBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Porto, Portugal; Instituto de Matemática e Estatística, Universidade de São Paulo, Brazil.

Liverpool School of Tropical Medicine, United Kingdom; Malawi Liverpool Wellcome Trust Programme of Clinical Tropical Research, Blantyre, Malawi.

出版信息

Vaccine. 2016 Jun 8;34(27):3007-3009. doi: 10.1016/j.vaccine.2016.04.065. Epub 2016 May 10.

DOI:10.1016/j.vaccine.2016.04.065
PMID:27177948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5087849/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7b2/5418366/fa1c4606aeea/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7b2/5418366/fa1c4606aeea/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7b2/5418366/fa1c4606aeea/gr1.jpg

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Design, recruitment, and microbiological considerations in human challenge studies.人体挑战研究的设计、招募和微生物学考虑因素。
Lancet Infect Dis. 2015 Jul;15(7):840-51. doi: 10.1016/S1473-3099(15)00068-7. Epub 2015 May 27.
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A missing dimension in measures of vaccination impacts.
加州州立监狱中囚犯的 2019 年冠状病毒病(COVID-19)疫苗有效性:回顾性队列研究。
Clin Infect Dis. 2022 Aug 24;75(1):e838-e845. doi: 10.1093/cid/ciab1032.
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Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19.单剂 Ad26.COV2.S 疫苗预防新冠病毒的安全性和有效性。
N Engl J Med. 2021 Jun 10;384(23):2187-2201. doi: 10.1056/NEJMoa2101544. Epub 2021 Apr 21.
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Pathogen transmission from vaccinated hosts can cause dose-dependent reduction in virulence.疫苗接种宿主传播病原体可导致毒力呈剂量依赖性降低。
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