Wan Cheng-Fu, Zheng Li-Li, Liu Yan, Yu Xue
Department of Anesthesiology, The First Hospital of China Medical University Shenyang City, Liaoning Province, P. R. China.
Department of Endocrinology, The 4th Affiliated Hospital of China Medical University Shenyang City, P. R. China.
Am J Transl Res. 2016 Mar 15;8(3):1609-14. eCollection 2016.
Oxaliplatin is a widely used anti-advanced colorectal cancer drug, while it could induce neuropathy. Houttuynia cordata Thunb (HCT) has a wide range of biological activities, such as anti-inflammation, anti-cancer, and immune regulation. In the present study, we investigated the effect of HCT on oxaliplatin-induced neuropathy in rat models. HCT (1000 mg/kg/day) significantly decreased the number of withdrawal responses and the withdrawal latency in oxaliplatin-treated rats. HCT could down-regulated the serum levels of Interleukin-6 (IL-6) and macrophage inflammatory protein1-α (MIP-1α) in oxaliplatin-treated rats. Th17/Treg balance was reversed by HCT in oxaliplatin-treated rats by regulating PI3K/Akt/mTOR signaling pathway. The present results suggest that HCT is useful as a therapeutic drug for oxaliplatin-induced neuropathic pain.
奥沙利铂是一种广泛使用的抗晚期结直肠癌药物，但其会诱发神经病变。鱼腥草具有广泛的生物学活性，如抗炎、抗癌和免疫调节作用。在本研究中，我们调查了鱼腥草对大鼠模型中奥沙利铂诱发神经病变的影响。鱼腥草（1000毫克/千克/天）显著减少了奥沙利铂处理大鼠的撤药反应次数和撤药潜伏期。鱼腥草能够下调奥沙利铂处理大鼠血清中白细胞介素-6（IL-6）和巨噬细胞炎性蛋白1-α（MIP-1α）的水平。在奥沙利铂处理的大鼠中，鱼腥草通过调节PI3K/Akt/mTOR信号通路逆转了Th17/Treg平衡。目前的结果表明，鱼腥草可作为治疗奥沙利铂诱发神经性疼痛的药物。
