Rigano Daniela, Marrelli Mariangela, Formisano Carmen, Menichini Francesco, Senatore Felice, Bruno Maurizio, Conforti Filomena
a Department of Pharmacy , University of Naples "Federico II" , Naples , Italy.
b Department of Pharmacy, Health and Nutritional Sciences , University of Calabria , Rende (CS) , Italy.
Nat Prod Res. 2017 Feb;31(4):436-444. doi: 10.1080/14786419.2016.1185722. Epub 2016 May 17.
Three Ballota species, Ballota undulata, Ballota saxatilis and Ballota nigra ssp. foetida, were investigated for their cytotoxicity against two human cancer cells, hepatoma HepG2 cell line and breast cancer MCF-7 cell line, and for their antioxidant activity. The chemical composition of essential oils was studied by GC and GC-MS. Sesquiterpenes were the main constituents. The most antiproliferative essential oil against HepG2 cells was B. undulata with a percentage of inhibition of 81.36 ± 3.54 at a concentration of 100 μg/mL, while against MCF-7 cells essential oil from B. saxatilis was the most active with a percentage of inhibition of 24.18 ± 1.13 at a concentration of 100 μg/mL. The antioxidant activity was investigated by DPPH test for all the oils. B. undulata showed the highest antiradical effect, with IC value of 529.7 ± 37.4 μg/mL.
对三种巴洛塔属植物，即波状巴洛塔、岩生巴洛塔和臭巴洛塔亚种，进行了针对两种人类癌细胞（肝癌HepG2细胞系和乳腺癌MCF-7细胞系）的细胞毒性及其抗氧化活性的研究。通过气相色谱（GC）和气相色谱 - 质谱联用（GC-MS）对精油的化学成分进行了研究。倍半萜是主要成分。对HepG2细胞增殖抑制作用最强的精油是波状巴洛塔，在浓度为100μg/mL时抑制率为81.36±3.54%，而对MCF-7细胞，岩生巴洛塔的精油活性最强，在浓度为100μg/mL时抑制率为24.18±1.13%。通过DPPH试验对所有精油的抗氧化活性进行了研究。波状巴洛塔表现出最高的抗自由基效果，IC值为529.7±37.4μg/mL。
