Yazgan-Ekici Ayse Nur, Bakar-Ates Filiz, Sever-Yilmaz Betul, Aslan-Erdem Sinem
Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, Ankara, Türkiye.
Department of Pharmacy Services, Ankara University, Vocational School of Health Services, Ankara, Türkiye.
Comb Chem High Throughput Screen. 2025;28(7):1145-1152. doi: 10.2174/0113862073319327240614113859.
native to the Mediterranean region, belonging to the Lamiaceae family, holds significance in folk medicine. Externally, it is applied for treating cuts and burns, while internally, it is utilized to alleviate inflammation, suppress cough, and address gastrointestinal issues.
This study aimed to investigate the chemical composition of the essential oil of Ballota acetabulosa and to evaluate the antioxidant capacity of the essential oil, as well as the aqueous and ethanolic extracts of the plant. Essential oil analysis was performed using Gas Chromatography- Mass Spectrometry (GC-MS), while 1,1-Diphenyl-2-Picrylhydrazyl (DPPH) radical scavenging activity and inhibition of lipid peroxidation assays were applied to the essential oil, water, and ethanol extracts of the plant.
Spathulenol was found to be the predominant constituent of the essential oil, comprising 25.03% of the oil. Compared to the control group (Propyl gallate for DPPH, IC 0.109; BHT for inhibition of lipid peroxidation, IC 0.133), the essential oil was found to have insignificant antioxidant activity (IC value 10.395 mg/mL for DPPH, 1.051 mg/mL for inhibition of lipid peroxidation). Moreover, ethanolic extract (IC value 1.583 mg/mL for DPPH, 0.029 mg/mL for inhibition of lipid peroxidation) exerted more antioxidant activity than aqueous extract (IC value 1.9017 mg/mL for DPPH, 0.161 mg/mL for inhibition of lipid peroxidation).
Hitherto, this is the earliest report on the composition and activity of the essential oil Ballota acetabulosa. However, further investigation of different antioxidant capacity assays is suggested to highlight potential variations in mechanisms of action and subsequent results. Everything considered, this study advances the comprehension of the chemical composition and possible therapeutic uses of , highlighting the need for more research into its uses.
原产于地中海地区，属于唇形科，在民间医学中具有重要意义。在外部，它用于治疗伤口和烧伤，在内部，它用于减轻炎症、止咳和解决胃肠道问题。
本研究旨在调查醋栗薄荷精油的化学成分，并评估该精油以及该植物的水提取物和乙醇提取物的抗氧化能力。使用气相色谱 - 质谱联用仪（GC - MS）进行精油分析，同时将1,1 - 二苯基 - 2 - 苦基肼（DPPH）自由基清除活性和脂质过氧化抑制试验应用于该植物的精油、水提取物和乙醇提取物。
发现匙叶桉油烯醇是精油的主要成分，占精油的25.03%。与对照组（DPPH用没食子酸丙酯，IC 0.109；脂质过氧化抑制用丁基羟基甲苯，IC 0.133）相比，发现该精油具有微不足道的抗氧化活性（DPPH的IC值为10.395 mg/mL，脂质过氧化抑制的IC值为1.051 mg/mL）。此外，乙醇提取物（DPPH的IC值为1.583 mg/mL，脂质过氧化抑制的IC值为0.029 mg/mL）比水提取物（DPPH的IC值为1.9017 mg/mL，脂质过氧化抑制的IC值为0.161 mg/mL）具有更强的抗氧化活性。
迄今为止，这是关于醋栗薄荷精油成分和活性的最早报告。然而，建议进一步研究不同的抗氧化能力测定方法，以突出作用机制和后续结果的潜在差异。综合考虑，本研究推进了对醋栗薄荷化学成分和可能治疗用途的理解，强调了对其用途进行更多研究的必要性。
