Sturgeon Kathleen, Digiovanni Laura, Good Jerene, Salvatore Domenick, Fenderson Desiré, Domchek Susan, Stopfer Jill, Galantino Mary Lou, Bryan Cathy, Hwang Wei-Ting, Schmitz Kathryn
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Cancer Epidemiol Biomarkers Prev. 2016 Aug;25(8):1195-200. doi: 10.1158/1055-9965.EPI-15-1087. Epub 2016 May 13.
Dysregulation of adipokines, such as adiponectin and leptin, is associated with a variety of chronic diseases, including cancer. Physical activity protects against breast cancer and one of the mechanisms which may underlie this association is exercise-induced changes in adipokine levels. The WISER Sister Trial was a three-armed randomized controlled trial in premenopausal women (n = 137) with an elevated risk for breast cancer.
A 5-menstrual-cycle-long dosed aerobic exercise intervention compared low-dose exercise (150 min/wk; n = 44) or high-dose exercise (300 min/wk; n = 48) with a control group asked to maintain usual activity levels (n = 45). Exercise intensity progressed to and was maintained at 70% to 80% of age predicted heart rate max. Body composition and adipokine levels were measured at baseline and follow-up.
We observed significant linear trends for increased fitness capacity (Δ%: -2.0% control, 10.1% low dose, 13.1% high dose), decreased fat tissue-to-total tissue mass (Δ%: 0.7% control, -2.9% low dose, -3.7% high dose), increased body fat adjusted adiponectin (Δ%: -0.6% control, 0.6% low dose, 0.9% high dose), and decreased body fat adjusted leptin (Δ%: 0.7% control, -8.2% low dose, -10.2% high dose).
In this randomized clinical trial of premenopausal women at risk for breast cancer, we demonstrate a dose-response effect of exercise on adiponectin and leptin and that dose response is dependent on changes in body fat.
Improved adipokine levels, achieved by aerobic exercise training-induced decreases in body fat, may decrease breast cancer risk for high-risk premenopausal women. Cancer Epidemiol Biomarkers Prev; 25(8); 1195-200. ©2016 AACR.
脂联素和瘦素等脂肪因子失调与包括癌症在内的多种慢性疾病相关。体育活动可预防乳腺癌，这种关联背后的机制之一可能是运动引起的脂肪因子水平变化。WISER姐妹试验是一项针对乳腺癌风险升高的绝经前女性（n = 137）的三臂随机对照试验。
一项为期5个月经周期的定量有氧运动干预，将低剂量运动（150分钟/周；n = 44）或高剂量运动（300分钟/周；n = 48）与要求维持日常活动水平的对照组（n = 45）进行比较。运动强度逐渐增加至并维持在年龄预测最大心率的70%至80%。在基线和随访时测量身体成分和脂肪因子水平。
我们观察到健身能力增加（变化百分比：对照组-2.0%，低剂量组10.1%，高剂量组13.1%）、脂肪组织与总组织质量比值降低（变化百分比：对照组0.7%，低剂量组-2.9%，高剂量组-3.7%）、身体脂肪调整后的脂联素增加（变化百分比：对照组-0.6%，低剂量组0.6%，高剂量组0.9%）以及身体脂肪调整后的瘦素降低（变化百分比：对照组0.7%，低剂量组-8.2%，高剂量组-10.2%）存在显著线性趋势。
在这项针对有乳腺癌风险的绝经前女性的随机临床试验中，我们证明了运动对脂联素和瘦素的剂量反应效应，且该剂量反应取决于身体脂肪的变化。
通过有氧运动训练导致身体脂肪减少而实现的脂肪因子水平改善，可能会降低高危绝经前女性患乳腺癌的风险。《癌症流行病学、生物标志物与预防》；25(8)；1195 - 200。©2016美国癌症研究协会。
