突尼斯孕妇25-羟基维生素D水平与神经管缺陷的发生情况
Maternal 25-hydroxyvitamin D level and the occurrence of neural tube defects in Tunisia.
作者信息
Nasri Kaouther, Ben Fradj Mohamed K, Feki Moncef, Kaabechi Naziha, Sahraoui Mariem, Masmoudi Aida, Marrakchi Raja, Gaigi Soumeya S
机构信息
Faculty of Sciences of Bizerte, University of Carthage, Zarzouna, Bizerte, Tunisia; UR06/SP14 Disorders of Embryo-Fetal and Placental Development, Service of Embryo-Fetopathology, Center for Maternity and Neonatology of Tunis, Faculty of Medicine, Tunis El Manar University, Tunis, Tunisia.
UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine, Tunis El Manar University, Jebbari, Tunis, Tunisia.
出版信息
Int J Gynaecol Obstet. 2016 Aug;134(2):131-4. doi: 10.1016/j.ijgo.2016.01.014. Epub 2016 May 4.
OBJECTIVE
To determine whether low vitamin D levels in pregnant women are associated with the occurrence of neural tube defects (NTDs) in Tunisia.
METHODS
In a prospective study, pregnant women were recruited at a center in Tunis between January 1, 2012, and December 30, 2013. Women carrying a fetus with a severe NTD were recruited before elective termination. Matched, healthy pregnancy women were enrolled into a control group. Plasma levels of 25-hydroxyvitamin D were measured by a competitive chemiluminescence immunoassay.
RESULTS
Overall, 68 women formed the NTD group and 64 the control group. The mean maternal vitamin D level was significantly lower in the NTD group (20.65±10.25nmol/L) than in the control group (28.30±13.82nmol/L; P<0.001). Vitamin D deficiency was recorded for 53 (78%) women in the NTD group and 39 (61%) in the control group. Vitamin D insufficiency was recorded for 15 (22%) women in the NTD group and 20 (31%) in the control group. Vitamin D sufficiency was found only in the control group (n=5 [8%]; P<0.001).
CONCLUSION
The findings confirm an association between a decreased vitamin D level in pregnant women and the risk of fetal NTDs.
目的
确定突尼斯孕妇维生素D水平低是否与神经管缺陷（NTDs）的发生有关。
方法
在一项前瞻性研究中，于2012年1月1日至2013年12月30日期间在突尼斯的一个中心招募孕妇。怀有严重神经管缺陷胎儿的妇女在选择性终止妊娠前被招募。匹配的健康孕妇被纳入对照组。采用竞争性化学发光免疫分析法测定血浆25-羟基维生素D水平。
结果
总体而言，68名妇女组成神经管缺陷组，64名组成对照组。神经管缺陷组孕妇的平均维生素D水平（20.65±10.25nmol/L）显著低于对照组（28.30±13.82nmol/L；P<0.001）。神经管缺陷组53名（78%）妇女存在维生素D缺乏，对照组39名（61%）。神经管缺陷组15名（22%）妇女存在维生素D不足，对照组20名（31%）。仅在对照组中发现维生素D充足（n = 5 [8%]；P<0.001）。
结论
研究结果证实孕妇维生素D水平降低与胎儿神经管缺陷风险之间存在关联。
Zotero 插件