Wang Hongliang, Tai Andrew W
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Viruses. 2016 May 20;8(5):142. doi: 10.3390/v8050142.
Like all positive-sense RNA viruses, hepatitis C virus (HCV) induces host membrane alterations for its replication termed the membranous web (MW). Assembling replication factors at a membranous structure might facilitate the processes necessary for genome replication and packaging and shield viral components from host innate immune defenses. The biogenesis of the HCV MW is a complex process involving a concerted effort of HCV nonstructural proteins with a growing list of host factors. Although a comprehensive understanding of MW formation is still missing, a number of important viral and host determinants have been identified. This review will summarize the recent studies that have led to our current knowledge of the role of viral and host factors in the biogenesis of the MWs and discuss how HCV uses this specialized membrane structure for its replication.
与所有正链RNA病毒一样，丙型肝炎病毒（HCV）在其复制过程中会诱导宿主膜发生改变，形成所谓的膜状网（MW）。在膜结构上组装复制因子可能有助于基因组复制和包装所需的过程，并保护病毒成分免受宿主先天免疫防御的影响。HCV膜状网的生物发生是一个复杂的过程，涉及HCV非结构蛋白与越来越多的宿主因子的协同作用。尽管对膜状网形成的全面理解仍然缺失，但已经确定了一些重要的病毒和宿主决定因素。本综述将总结最近的研究，这些研究使我们目前了解病毒和宿主因子在膜状网生物发生中的作用，并讨论HCV如何利用这种特殊的膜结构进行复制。
