Gomez-Arango Luisa F, Barrett Helen L, McIntyre H David, Callaway Leonie K, Morrison Mark, Dekker Nitert Marloes
School of Medicine, The University of Queensland, Brisbane, Queensland, Australia The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.
School of Medicine, The University of Queensland, Brisbane, Queensland, Australia The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia Obstetric Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Diabetes. 2016 Aug;65(8):2214-23. doi: 10.2337/db16-0278. Epub 2016 May 23.
Overweight and obese women are at a higher risk for gestational diabetes mellitus. The gut microbiome could modulate metabolic health and may affect insulin resistance and lipid metabolism. The aim of this study was to reveal relationships between gut microbiome composition and circulating metabolic hormones in overweight and obese pregnant women at 16 weeks' gestation. Fecal microbiota profiles from overweight (n = 29) and obese (n = 41) pregnant women were assessed by 16S rRNA sequencing. Fasting metabolic hormone (insulin, C-peptide, glucagon, incretin, and adipokine) concentrations were measured using multiplex ELISA. Metabolic hormone levels as well as microbiome profiles differed between overweight and obese women. Furthermore, changes in some metabolic hormone levels were correlated with alterations in the relative abundance of specific microbes. Adipokine levels were strongly correlated with Ruminococcaceae and Lachnospiraceae, which are dominant families in energy metabolism. Insulin was positively correlated with the genus Collinsella. Gastrointestinal polypeptide was positively correlated with the genus Coprococcus but negatively with family Ruminococcaceae This study shows novel relationships between gut microbiome composition and the metabolic hormonal environment in overweight and obese pregnant women at 16 weeks' gestation. These results suggest that manipulation of the gut microbiome composition may influence pregnancy metabolism.
超重和肥胖女性患妊娠期糖尿病的风险更高。肠道微生物群可调节代谢健康，并可能影响胰岛素抵抗和脂质代谢。本研究的目的是揭示妊娠16周时超重和肥胖孕妇的肠道微生物群组成与循环代谢激素之间的关系。通过16S rRNA测序评估超重（n = 29）和肥胖（n = 41）孕妇的粪便微生物群谱。使用多重ELISA测量空腹代谢激素（胰岛素、C肽、胰高血糖素、肠促胰岛素和脂肪因子）浓度。超重和肥胖女性的代谢激素水平以及微生物群谱存在差异。此外，一些代谢激素水平的变化与特定微生物相对丰度的改变相关。脂肪因子水平与能量代谢中的优势菌科瘤胃球菌科和毛螺菌科密切相关。胰岛素与柯林斯菌属呈正相关。胃肠多肽与粪球菌属呈正相关，但与瘤胃球菌科呈负相关。本研究揭示了妊娠16周时超重和肥胖孕妇肠道微生物群组成与代谢激素环境之间的新关系。这些结果表明，操纵肠道微生物群组成可能会影响妊娠代谢。
