a UQ Centre for Clinical Research, The University of Queensland , Brisbane , Australia.
b Faculty of Medicine, The University of Queensland , Brisbane , Australia.
Gut Microbes. 2018;9(3):189-201. doi: 10.1080/19490976.2017.1406584. Epub 2018 Mar 13.
The gut microbiota contributes to the regulation of glucose metabolism in pregnancy. Abundance of the genus Collinsella is positively correlated with circulating insulin; however, it is unclear what determines Collinsella abundance. This study aims to validate the correlation between Collinsella and insulin and to elucidate if macronutrient intake alters Collinsella abundance and gut microbiota composition. Gut microbiota profiles were assessed by 16S rRNA sequencing in 57 overweight and 73 obese pregnant women from the SPRING (Study of PRobiotics IN Gestational diabetes) trial at 16 weeks gestation and correlated with metabolic hormone levels and macronutrient intake. Gut microbiota composition in the top and bottom 10% of dietary fiber intake was evaluated through network analysis. Collinsella abundance correlated positively with circulating insulin (rho = 0.30, p = 0.0006), independent of maternal BMI, but negatively with dietary fiber intake (rho = -0.20, p = 0.025) in this cohort. Low dietary fiber intake was associated with a gut microbiota favoring lactate fermentation while high fiber intake promotes short-chain fatty acid-producing bacteria. Low dietary fiber may enable overgrowth of Collinsella and alter the overall fermentation pattern in gut microbiota. This suggests that dietary choices during pregnancy can modify the nutritional ecology of the gut microbiota, with potential deleterious effects on the metabolic and inflammatory health of the host.
ANZCTR 12611001208998, registered 23/11/2011.
肠道微生物群有助于调节妊娠期间的葡萄糖代谢。柯林斯菌属的丰度与循环胰岛素呈正相关；然而，尚不清楚是什么决定了柯林斯菌属的丰度。本研究旨在验证柯林斯菌属与胰岛素之间的相关性，并阐明宏量营养素的摄入是否改变柯林斯菌属的丰度和肠道微生物群组成。在 SPRING（妊娠糖尿病益生菌研究）试验中，对 57 名超重和 73 名肥胖孕妇在妊娠 16 周时进行了 16S rRNA 测序，评估了肠道微生物群图谱，并与代谢激素水平和宏量营养素摄入相关。通过网络分析评估了膳食纤维摄入量最高和最低的 10%的肠道微生物群组成。在本队列中，柯林斯菌属的丰度与循环胰岛素呈正相关（rho=0.30，p=0.0006），与母体 BMI 无关，但与膳食纤维摄入呈负相关（rho=-0.20，p=0.025）。膳食纤维摄入低与有利于乳酸发酵的肠道微生物群有关，而高膳食纤维摄入则促进产生短链脂肪酸的细菌。低膳食纤维摄入可能会使柯林斯菌属过度生长，并改变肠道微生物群的整体发酵模式。这表明妊娠期间的饮食选择可以改变肠道微生物群的营养生态，对宿主的代谢和炎症健康产生潜在的有害影响。
ANZCTR 12611001208998，注册于 2011 年 11 月 23 日。
