Harland C, Shah T, Webster A D, Peters T J
Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, UK.
Int Arch Allergy Appl Immunol. 1989;88(4):471-3. doi: 10.1159/000234734.
Serum neopterin was measured in patients with acquired 'common variable' hypogammaglobulinaemia (CVH), X-linked agammaglobulinaemia (XLA) and healthy subjects. There was a highly significant increase in neopterin levels in the CVH patients as compared with that of the other groups, particularly in those CVH patients with non-A non-B or granulomatous hepatitis. There was no association between raised neopterin levels and chronic infective lung disease. Since chronic viral infections are associated with raised serum neopterin, this data add some support to a viral aetiology for CVH.
对获得性“常见变异型”低丙种球蛋白血症（CVH）、X连锁无丙种球蛋白血症（XLA）患者及健康受试者测定了血清新蝶呤水平。与其他组相比，CVH患者的新蝶呤水平显著升高，尤其是那些患有非甲非乙型肝炎或肉芽肿性肝炎的CVH患者。新蝶呤水平升高与慢性感染性肺病之间无关联。由于慢性病毒感染与血清新蝶呤升高有关，这些数据为CVH的病毒病因学提供了一些支持。
