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伏格特-小柳-原田综合征与血清阴性类风湿关节炎的关联

Association of Vogt Koyanagi Harada Syndrome and Seronegative Rheumatoid Arthritis.

作者信息

Aydin Teoman, Taspinar Ozgur, Guneser Meryem, Keskin Yasar

机构信息

Bezm-i Alem Foundation University School Of Medicine, Department Of Physical Therapy And Rehabilitation, Istanbul.

Cinarcik State Hospital, Department Of Physical Therapy And Rehabilitation, Yalova.

出版信息

Ethiop J Health Sci. 2016 Mar;26(2):193-6. doi: 10.4314/ejhs.v26i2.14.

Abstract

BACKGROUND

Vogt Koyanagi Harada (VKH) Syndrome is a rarely-seen multi-systemic, autoimmune and inflammatory disease. It observed frequently with neurologic, auditory and skin manifestations and characterized with bilateral, chronic and diffused granulomatous panuveitis. It generally affects women in young-adult period.

CASE

A 57 year-old female patient applied to a special center one year ago with a complaint of decrease in the sight acuity of the right eye. The right eye was operated on with cataract diagnosis. Uveitis was developed firstly in the right eye and then in the left eye after the operation. Having complaints about uveitis, tinnitus and hear loss, the patient was diagnosed with VKH syndrome. The pains started to be felt in small hand joints and both of the two ankles. The pains were increasing especially in the mornings and during rest. The duration of morning stiffness was two hours in hand and foot joints. The patient had had lumbar pain with mechanic characteristic for five years.

CONCLUSION

Being diagnosed with seronegative rheumatoid arthritis (RA), our case is presented because VKH syndrome is rarely seen in Turkey, and the joint findings are at the forefront.

摘要

背景

伏格特-小柳-原田(VKH)综合征是一种罕见的多系统自身免疫性炎症性疾病。其常伴有神经、听觉和皮肤表现,特征为双侧慢性弥漫性肉芽肿性全葡萄膜炎。该病通常在青年成年期影响女性。

病例

一名57岁女性患者于一年前因右眼视力下降就诊于一家专科中心。经诊断为白内障后,右眼接受了手术。术后右眼首先出现葡萄膜炎,随后左眼也出现。患者因葡萄膜炎、耳鸣和听力损失前来就诊,被诊断为VKH综合征。患者开始感到小手关节和双侧脚踝疼痛。疼痛尤其在早晨和休息时加剧。手足关节晨僵持续时间为两小时。患者有五年的机械性特征的腰痛。

结论

我们的病例被诊断为血清阴性类风湿关节炎(RA),之所以呈现该病例是因为VKH综合征在土耳其很少见,且关节表现最为突出。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02fa/4864349/b05034f26835/EJHS2602-0193Fig1.jpg

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